Department of Physiology, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
Department of Medical Biotechnology and Nanotechnology, School of Science, Mashhad University of Medical Science, Mashhad, Iran.
Mini Rev Med Chem. 2023;23(9):1033-1049. doi: 10.2174/1389557522666220512142842.
Colorectal cancer is a leading cause of death among cancers worldwide, with the symptoms mimicking other far more common lower gastrointestinal disorders.
This challenge in separating colorectal cancer from other diseases has driven researchers to investigate a noninvasive screening technique and effective method. The early detection of colorectal cancer is imperative. Biomarkers play a critical role in colorectal screening tests, treatment, clinical and prognosis management. Therefore, sensitive and rapid biomarker detection would be helpful and demand the early diagnosis of colorectal cancer.
Recently, several investigations have been performed to design biosensors for early detection of cancer diagnosis and profiling with strong applied ability and high sensitivity.
In comparison, optical biosensors are one of the promising platforms for the costeffective and rapid detection of biomarkers. This review will focus on the advancements and progress of the various optical-transducing approaches for diagnosing colorectal cancer.
Further, the prospects and limitations of these optical biosensors in colorectal cancer diagnosis will be discussed. Here, an overview of optical biosensors and meaningful information for scientists worldwide will be demonstrated.
结直肠癌是全球癌症死亡的主要原因，其症状类似于其他更为常见的下消化道疾病。
这种将结直肠癌与其他疾病区分开来的挑战促使研究人员研究一种非侵入性的筛查技术和有效的方法。早期发现结直肠癌至关重要。生物标志物在结直肠筛查试验、治疗、临床和预后管理中起着关键作用。因此，敏感和快速的生物标志物检测将是有帮助的，并需要早期诊断结直肠癌。
最近，已经进行了几项研究来设计用于早期癌症诊断和分析的生物传感器，具有很强的应用能力和高灵敏度。
相比之下，光学生物传感器是用于检测生物标志物的具有成本效益且快速的有前途的平台之一。本综述将重点介绍用于诊断结直肠癌的各种光转换方法的进展和进展。
此外，还将讨论这些光学生物传感器在结直肠癌诊断中的前景和局限性。在这里，将概述光学生物传感器并为全世界的科学家提供有意义的信息。
