Ranjbari Sara, Darroudi Mahdieh, Hatamluyi Behnaz, Arefinia Reza, Aghaee-Bakhtiari Seyed Hamid, Rezayi Majid, Khazaei Majid
Chemical Engineering Department, Faculty of Engineering, Ferdowsi University of Mashhad, Mashhad, Iran.
Department of Physiology, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
Front Bioeng Biotechnol. 2022 Aug 24;10:984336. doi: 10.3389/fbioe.2022.984336. eCollection 2022.
Breast cancer is the second most common cancer worldwide. Prognosis and timely treatment can reduce the illness or improve it. The use of nanomaterials leads to timely diagnosis and effective treatment. MXenes are a 2D material with a unique composition of attributes, containing significant electrical conductance, high optical characteristics, mechanical consistency, and excellent optical properties. Current advances and insights show that MXene is far more promising in biotechnology applications than current nanobiotechnology systems. MXenes have various applications in biotechnology and biomedicine, such as drug delivery/loading, biosensor, cancer treatment, and bioimaging programs due to their high surface area, excellent biocompatibility, and physicochemical properties. Surface modifications MXenes are not only biocompatible but also have multifunctional properties, such as aiming ligands for preferential agglomeration at the tumor sites for photothermal treatment. Studies have shown that these nanostructures, detection, and breast cancer therapy are more acceptable than present nanosystems in and . This review article aims to investigate the structure of MXene, its various synthesis methods, its application to cancer diagnosis, cytotoxicity, biodegradability, and cancer treatment by the photothermal process ( and ).
乳腺癌是全球第二大常见癌症。预后和及时治疗可以减轻病情或改善病情。纳米材料的使用有助于及时诊断和有效治疗。MXenes是一种二维材料,具有独特的属性组成,包括显著的电导率、高光学特性、机械一致性和优异的光学性能。当前的进展和见解表明,MXene在生物技术应用方面比当前的纳米生物技术系统更具前景。由于其高比表面积、优异的生物相容性和物理化学性质,MXenes在生物技术和生物医学中有多种应用,如药物递送/负载、生物传感器、癌症治疗和生物成像程序。表面修饰的MXenes不仅具有生物相容性,还具有多功能特性,例如用于在肿瘤部位进行光热治疗的靶向配体,以实现优先聚集。研究表明,这些纳米结构、检测方法和乳腺癌治疗方法比目前的纳米系统在[具体方面1]和[具体方面2]更具可接受性。这篇综述文章旨在研究MXene的结构、其各种合成方法、其在癌症诊断中的应用、细胞毒性、生物降解性以及通过光热过程进行的癌症治疗([具体方面3]和[具体方面4])。