Division of Gastroenterology, Department of Internal Medicine, Aksaray University Education and Research Hospital, Aksaray, Turkey.
Department of Gastroenterology, Mersin City Training and Research Hospital, Mersin, Turkey.
Turk J Gastroenterol. 2022 Apr;33(4):329-335. doi: 10.5152/tjg.2022.21401.
In patients with ulcerative colitis, endoscopic and clinical indices are used to assess the disease activity. In addition, stud- ies have been carried out for easier and cheaper markers in recent years. For this purpose, we evaluated the monocyte/high-density lipoprotein ratio of the disease activity.
According to clinical activity and partial Mayo scores, a total of 114 patients, 53 in the active ulcerative colitis group and 61 in the ulcerative colitis remission group were included in the study. Monocyte/high-density lipoprotein ratio, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, C-reactive protein, and erythrocyte sedimentation rate measurements of these 2 groups were recorded. Ulcerative colitis remission group and active ulcerative colitis group were compared in terms of activity.
The monocyte/high-density lipoprotein ratio value in the active ulcerative colitis group was significantly higher than that of the ulcerative colitis remission group (10.68 ± 3.39, 6.68 ± 1.39, P < .001, respectively). The monocyte/high-density lipoprotein ratio value for active ulcerative colitis at a cut-off value of 7.4 had 83% sensitivity and 81% specificity. In the active ulcerative colitis group, neutrophil/lymphocyte ratio, C-reactive protein, and erythrocyte sedimentation rate values were significantly higher than the ulcerative colitis remission group (P < .001, P < .001, P < .001, respectively).
Monocyte/high-density lipoprotein ratio is an inexpensive and effective marker that can be used to determine the activity of ulcerative colitis.
在溃疡性结肠炎患者中，内镜和临床指数用于评估疾病活动度。此外，近年来已经进行了研究，以寻找更简单、更廉价的标志物。为此，我们评估了疾病活动度的单核细胞/高密度脂蛋白比值。
根据临床活动度和部分 Mayo 评分，共纳入 114 例患者，其中活动期溃疡性结肠炎组 53 例，溃疡性结肠炎缓解组 61 例。记录两组的单核细胞/高密度脂蛋白比值、中性粒细胞/淋巴细胞比值、血小板/淋巴细胞比值、C 反应蛋白和红细胞沉降率。比较溃疡性结肠炎缓解组和活动期溃疡性结肠炎组的活动度。
活动期溃疡性结肠炎组的单核细胞/高密度脂蛋白比值明显高于溃疡性结肠炎缓解组（10.68±3.39，6.68±1.39，P<0.001）。单核细胞/高密度脂蛋白比值为 7.4 时，对活动期溃疡性结肠炎的敏感性为 83%，特异性为 81%。活动期溃疡性结肠炎组的中性粒细胞/淋巴细胞比值、C 反应蛋白和红细胞沉降率均明显高于溃疡性结肠炎缓解组（P<0.001，P<0.001，P<0.001）。
单核细胞/高密度脂蛋白比值是一种廉价且有效的标志物，可用于确定溃疡性结肠炎的活动度。
