National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, 430074, Wuhan, China.
Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China.
Nat Commun. 2022 May 12;13(1):2625. doi: 10.1038/s41467-022-30263-1.
X-ray computed tomography (CT) has an important role in precision medicine. However, CT contrast agents with high efficiency and the ability to translate diagnostic accuracy into therapeutic intervention are scarce. Here, poly(diiododiacetylene) (PIDA), a conjugated polymer composed of only carbon and iodine atoms, is reported as an efficient CT contrast agent to bridge CT diagnostic imaging with therapeutic intervention. PIDA has a high iodine payload (>84 wt%), and the aggregation of nanofibrous PIDA can further amplify CT intensity and has improved geometrical and positional stability in vivo. Moreover, with a conjugated backbone, PIDA is in deep blue color, making it dually visible by both CT imaging and the naked eyes. The performance of PIDA in CT-guided preoperative planning and visualization-guided surgery is validated using orthotopic xenograft rat models. In addition, PIDA excels clinical fiducial markers of imaging-guided radiotherapy in efficiency and biocompatibility, and exhibits successful guidance of robotic radiotherapy on Beagles, demonstrating clinical potential to translate CT diagnosis accuracy into therapeutic intervention for precision medicine.
X 射线计算机断层扫描（CT）在精准医学中具有重要作用。然而，具有高效能且能够将诊断准确性转化为治疗干预的 CT 对比剂却很匮乏。在此，报告了一种由仅由碳和碘原子组成的共轭聚合物聚二碘二乙炔（PIDA），可作为一种有效的 CT 对比剂，将 CT 诊断成像与治疗干预联系起来。PIDA 具有高碘载量（>84wt%），纳米纤维状 PIDA 的聚集可进一步放大 CT 强度，并提高体内的几何和位置稳定性。此外，由于具有共轭主链，PIDA 呈深蓝色，使其既可以通过 CT 成像又可以通过肉眼双重可视化。使用原位异种移植大鼠模型验证了 PIDA 在 CT 引导术前规划和可视化引导手术中的性能。此外，PIDA 在效率和生物相容性方面优于影像引导放疗的临床基准标记物，并成功指导了比格犬的机器人放疗，表明其具有将 CT 诊断准确性转化为精准医学治疗干预的临床潜力。
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