Genovese Tiziana, D'Amico Ramona, Fusco Roberta, Impellizzeri Daniela, Peritore Alessio Filippo, Crupi Rosalia, Interdonato Livia, Gugliandolo Enrico, Cuzzocrea Salvatore, Paola Rosanna Di, Siracusa Rosalba, Cordaro Marika
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Cell Physiol Biochem. 2022 May 13;56(S2):1-20. doi: 10.33594/000000529.
BACKGROUND/AIMS: Respiratory diseases are the world's biggest cause of mortality and disability. Specific nutrients have been proposed to positively affect disease progression as novel therapy alternatives to glucocorticosteroids. There has been a lot of attention in the possible health advantages of dietary assumption of Açai Seeds, popular native fruit found in the Amazon region which is rich in bioactive compounds. Until today nobody investigated the beneficial property of Açai Seeds administration in lung disease.
In our study we use two model of lung disease: for acute lung disease we use an intrapleural injection of Carrageenan; for chronic disease we used an intratracheal instillation of bleomycin. Açai Seeds was administered orally dissolved in saline.
We found that Açai Seeds was able to reduce histological alteration, cells infiltration, pro inflammatory cytokine release, inflammation, and oxidative stress in both acute and chronic model of lung disease.
Our data clearly demonstrate for the first time that Açai Seeds administration was useful against lung disease by the reduction of NF-κB nuclear translocation and by the stimulation of Nrf2/ARE pathways promoting the physiological antioxidant defense.
背景/目的：呼吸系统疾病是全球死亡和残疾的首要原因。已有研究提出特定营养素可作为糖皮质激素的新型替代疗法，对疾病进展产生积极影响。亚马逊地区一种富含生物活性化合物的本土流行水果——阿萨伊籽的饮食摄入可能带来的健康益处受到了广泛关注。迄今为止，尚无研究探讨阿萨伊籽给药对肺部疾病的有益特性。
在我们的研究中，我们使用了两种肺部疾病模型：对于急性肺部疾病，我们采用胸膜腔内注射角叉菜胶；对于慢性疾病，我们采用气管内滴注博来霉素。将阿萨伊籽溶解在盐水中口服给药。
我们发现，在急性和慢性肺部疾病模型中，阿萨伊籽均能够减轻组织学改变、细胞浸润、促炎细胞因子释放、炎症和氧化应激。
我们的数据首次清楚地表明，阿萨伊籽给药可通过减少核因子κB（NF-κB）核转位以及刺激核因子E2相关因子2/抗氧化反应元件（Nrf2/ARE）通路来促进生理性抗氧化防御，从而对肺部疾病产生有益作用。
