Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.
Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.
Cells. 2022 Aug 22;11(16):2616. doi: 10.3390/cells11162616.
The second-most common cause of dementia is vascular dementia (VaD). The majority of VaD patients experience cognitive impairment, which is brought on by oxidative stress and changes in autophagic function, which ultimately result in neuronal impairment and death. In this study, we examine a novel method for reversing VaD-induced changes brought on by açai berry supplementation in a VaD mouse model. The purpose of this study was to examine the impact of açai berries on the molecular mechanisms underlying VaD in a mouse model of the disease that was created by repeated ischemia-reperfusion (IR) of the whole bilateral carotid artery. Here, we found that açai berry was able to reduce VaD-induced behavioral alteration, as well as hippocampal death, in CA1 and CA3 regions. These effects are probably due to the modulation of nuclear factor erythroid 2-related factor 2 (Nrf-2) and Beclin-1, suggesting a possible crosstalk between these molecular pathways. In conclusion, the protective effects of açai berry could be a good supplementation in the future for the management of vascular dementia.
血管性痴呆（VaD）是痴呆的第二大常见病因。大多数 VaD 患者会出现认知功能障碍，这是由氧化应激和自噬功能变化引起的，最终导致神经元损伤和死亡。在这项研究中，我们研究了一种通过补充巴西莓来逆转 VaD 引起的变化的新方法，这种方法是在通过反复全双侧颈总动脉缺血再灌注（IR）建立的 VaD 小鼠模型中进行的。本研究旨在探讨巴西莓对通过反复全双侧颈总动脉缺血再灌注（IR）建立的 VaD 小鼠模型中疾病相关分子机制的影响。在这里，我们发现巴西莓能够减少 VaD 引起的行为改变，以及海马 CA1 和 CA3 区的死亡。这些作用可能是由于核因子红细胞 2 相关因子 2（Nrf-2）和 Beclin-1 的调节，提示这些分子途径之间可能存在串扰。总之，巴西莓的保护作用可能是未来血管性痴呆管理的一种良好补充。
