Pediatric Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland.
Clin Rev Allergy Immunol. 2022 Dec;63(3):490-498. doi: 10.1007/s12016-022-08940-2. Epub 2022 May 12.
Finkelstein-Seidlmayer vasculitis, also referred to as acute hemorrhagic edema of young children, is a rare small-vessel leukocytoclastic vasculitis. This condition is skin-limited, mainly affects infants up to 2 years of age and spontaneously remits. It has been suggested that an infection or a vaccine precede (by ≤ 14 days) this vasculitis. To better understand the interplay between infections or vaccines and Finkelstein-Seidlmayer vasculitis, we utilized the data contained in the Acute Hemorrhagic Edema BIbliographic Database AHEBID. The database, initiated in 2019, is being regularly updated, encompasses the entire original literature on Finkelstein-Seidlmayer vasculitis published after the original description and is attainable on request. The possible existence of an infectious or a vaccine precursor was addressed in 447 cases. Most cases were preceded by an infection (N = 384; 86%), by a vaccination (N = 20; 4.4%), or both an infection and a vaccination (N = 17; 3.8%). No precursor was reported in the remaining cases (N = 26; 5.8%). Two distinct infections preceded the onset of the vasculitis in 11 of the 381 cases with infection-associated Finkelstein-Seidlmayer vasculitis. The following infectious precursors were reported: upper respiratory tract infection (N = 292); acute gastroenteritis (N = 40); a benign febrile infection (N = 36); lower respiratory tract infection (N = 22); further infections (N = 8). The temporal relationship between the infectious precursor and the onset of the skin eruption was detailed in 336 cases: 54 cases developed before resolution and 282 after resolution of the infection. In conclusion, most cases of Finkelstein-Seidlmayer vasculitis are preceded by an infection. In a minority of cases, this skin vasculitis develops before resolution of the infection. In most cases, however, this vasculitis develops after resolution of the infection. More rarely, this vasculitis is preceded by a vaccination.
芬克尔斯坦-赛德曼血管炎，也称为儿童急性出血性水肿，是一种罕见的小血管白细胞碎裂性血管炎。这种疾病局限于皮肤，主要影响 2 岁以下的婴儿，并自发缓解。有研究表明，这种血管炎之前存在感染或疫苗接种（≤14 天）。为了更好地了解感染或疫苗接种与芬克尔斯坦-赛德曼血管炎之间的相互作用，我们利用了急性出血性水肿 BIbliographic 数据库 AHEBID 中包含的数据。该数据库于 2019 年启动，定期更新，包含自最初描述以来发表的关于芬克尔斯坦-赛德曼血管炎的所有原始文献，可根据要求提供。在 447 例病例中，探讨了感染或疫苗接种前体的可能存在。大多数病例之前存在感染（N=384；86%），接种疫苗（N=20；4.4%），或同时存在感染和接种疫苗（N=17；3.8%）。在其余病例（N=26；5.8%）中未报告前体。在 381 例与感染相关的芬克尔斯坦-赛德曼血管炎病例中，有 11 例血管炎发作前存在两种不同的感染。报告了以下感染前体：上呼吸道感染（N=292）；急性胃肠炎（N=40）；良性发热感染（N=36）；下呼吸道感染（N=22）；进一步感染（N=8）。在 336 例病例中详细描述了感染前体与皮肤疹发作之间的时间关系：54 例在感染缓解前出现，282 例在感染缓解后出现。总之，大多数芬克尔斯坦-赛德曼血管炎病例之前存在感染。在少数情况下，这种皮肤血管炎在感染缓解前出现。然而，在大多数情况下，这种血管炎在感染缓解后出现。更罕见的是，这种血管炎之前接种过疫苗。
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