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可控的一氧化氮存储和释放于 Cu-BTC：晶体学见解和生物活性。

Controllable Nitric Oxide Storage and Release in Cu-BTC: Crystallographic Insights and Bioactivity.

机构信息

Ingenium College of Liberal Arts (Chemistry), Kwangwoon University, Seoul 01897, Korea.

Department of Chemistry, Kwangwoon University, Seoul 01897, Korea.

出版信息

Int J Mol Sci. 2022 Aug 13;23(16):9098. doi: 10.3390/ijms23169098.

DOI:10.3390/ijms23169098
PMID:36012363
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9409197/
Abstract

Crystalline metal-organic frameworks (MOFs) are extensively used in areas such as gas storage and small-molecule drug delivery. Although Cu-BTC (, MOF-199, BTC: benzene-1,3,5-tricarboxylate) has versatile applications, its NO storage and release characteristics are not amenable to therapeutic usage. In this work, micro-sized Cu-BTC was prepared solvothermally and then processed by ball-milling to prepare nano-sized Cu-BTC (). The NO storage and release properties of the micro- and nano-sized Cu-BTC MOFs were morphology dependent. Control of the hydration degree and morphology of the NO delivery vehicle improved the NO release characteristics significantly. In particular, the nano-sized NO-loaded Cu-BTC (NO⊂nano-Cu-BTC, ) released NO at 1.81 µmol·mg in 1.2 h in PBS, which meets the requirements for clinical usage. The solid-state structural formula of NO⊂Cu-BTC was successfully determined to be [CuCHO]·(NO) through single-crystal X-ray diffraction, suggesting no structural changes in Cu-BTC upon the intercalation of 0.167 equivalents of NO within the pores of Cu-BTC after NO loading. The structure of Cu-BTC was also stably maintained after NO release. NO⊂Cu-BTC exhibited significant antibacterial activity against six bacterial strains, including Gram-negative and positive bacteria. NO⊂Cu-BTC could be utilized as a hybrid NO donor to explore the synergistic effects of the known antibacterial properties of Cu-BTC.

摘要

结晶金属-有机骨架（MOFs）在气体储存和小分子药物输送等领域得到了广泛应用。尽管 Cu-BTC（MOF-199，BTC：苯-1,3,5-三甲酸）具有多功能应用，但它的 NO 存储和释放特性不适用于治疗用途。在这项工作中，采用溶剂热法制备了微米级的 Cu-BTC，然后通过球磨处理制备了纳米级的 Cu-BTC（）。微米和纳米级 Cu-BTC MOFs 的 NO 存储和释放性能取决于形态。控制 NO 输送载体的水合程度和形态可以显著改善 NO 的释放特性。特别是，负载 NO 的纳米级 Cu-BTC（NO⊂nano-Cu-BTC，）在 PBS 中以 1.81 µmol·mg 在 1.2 h 内释放 NO，这符合临床使用的要求。通过单晶 X 射线衍射成功确定了 NO⊂Cu-BTC 的固体结构化学式为[CuCHO]·（NO），表明在负载 NO 后，Cu-BTC 中的孔内插入 0.167 当量的 NO 不会导致其结构发生变化。NO 释放后，Cu-BTC 的结构也保持稳定。NO⊂Cu-BTC 对六种细菌菌株表现出显著的抗菌活性，包括革兰氏阴性菌和阳性菌。NO⊂Cu-BTC 可用作混合 NO 供体，以探索已知具有抗菌性能的 Cu-BTC 的协同效应。

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2
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ACS Omega. 2020 Mar 11;5(11):5748-5755. doi: 10.1021/acsomega.9b03787. eCollection 2020 Mar 24.
3
Recent Innovation of Metal-Organic Frameworks for Carbon Dioxide Photocatalytic Reduction.
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Molecules. 2022 Nov 21;27(22):8073. doi: 10.3390/molecules27228073.
4
Applications of Nano/Micromotors for Treatment and Diagnosis in Biological Lumens.纳米/微米马达在生物腔道治疗与诊断中的应用。
Micromachines (Basel). 2022 Oct 19;13(10):1780. doi: 10.3390/mi13101780.
5
Frontiers in Antimicrobial Biomaterials.抗菌生物材料前沿
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