Hall Jeffrey D, Duncan-Gould Nathan W, Siddiqi Nasar A, Kelly Jennifer N, Hoeferlin L Alexis, Morrison Susan J, Wyatt Justin K
Department of Chemistry and Biochemistry, College of Charleston, 66 George Street, Charleston, SC 29424, USA.
Bioorg Med Chem. 2005 Feb 15;13(4):1409-13. doi: 10.1016/j.bmc.2004.10.018.
The antibiotic cytosporone E (isolated from the broth of the endophytic fungi CR 200 (Cytospora sp.) and CR 146 (Diaporthe sp.)) was synthesized as a racemic mixture. The key step in the synthesis is the Meyers ortho-alkylation of a chiral aromatic oxazoline. Preliminary antibiotic activity shows antibiosis against Gram-positive bacteria but not Gram-negative bacteria as previously reported.
抗生素环孢菌素E（从内生真菌CR 200（壳囊孢属）和CR 146（间座壳属）的发酵液中分离得到）被合成为外消旋混合物。合成中的关键步骤是手性芳族恶唑啉的迈耶斯邻位烷基化反应。初步的抗生素活性表明，它对革兰氏阳性菌具有抗菌作用，但对革兰氏阴性菌没有抗菌作用，这与之前报道的情况一致。
