Huang Jing, Zhou Yi
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University Wuhan 430079, China.
Department of Prosthodontics, Hospital of Stomatology, Wuhan University Wuhan 430079, China.
Am J Transl Res. 2022 Apr 15;14(4):2162-2183. eCollection 2022.
Periodontitis is mainly initiated by periodontal pathogens including , and bad living habits such as smoking aggravate its incidence and severity. The development of periodontitis is closely related to the host's immune responses and the secretion of various cytokine networks. Moreover, periodontitis has an important connection with the development of systemic diseases. Recently, epigenetics which is a fast-developing hot research area has provided new insights into the research of various diseases including periodontitis. Epigenetics is an important supplement to the regulation of gene expression. The study of epigenetics is about causing heritable gene expression or cell phenotype changes through certain mechanisms without changing the DNA sequence. It mainly includes histone modification, DNA methylation, non-coding RNA and the latest research hotspot m6A RNA methylation. In the review, we comprehensively summarize the latest literature on the potential epigenetic regulations in various aspects of periodontitis.
牙周炎主要由包括……在内的牙周病原体引发，吸烟等不良生活习惯会加重其发病率和严重程度。牙周炎的发展与宿主的免疫反应以及各种细胞因子网络的分泌密切相关。此外，牙周炎与全身性疾病的发展有着重要联系。最近，作为一个快速发展的热门研究领域的表观遗传学为包括牙周炎在内的各种疾病的研究提供了新的见解。表观遗传学是基因表达调控的重要补充。表观遗传学研究是通过某些机制在不改变DNA序列的情况下引起可遗传的基因表达或细胞表型变化。它主要包括组蛋白修饰、DNA甲基化、非编码RNA以及最新的研究热点m6A RNA甲基化。在这篇综述中，我们全面总结了关于牙周炎各方面潜在表观遗传调控的最新文献。
