Eunice Kennedy Shriver National Institute of Child Health and Development, Bethesda, MD 20892, USA.
Int J Mol Sci. 2022 Apr 19;23(9):4490. doi: 10.3390/ijms23094490.
Iron homeostasis disruption has increasingly been implicated in various neurological disorders. In this review, we present an overview of our current understanding of iron metabolism in the central nervous system. We examine the consequences of both iron accumulation and deficiency in various disease contexts including neurodegenerative, neurodevelopmental, and neuropsychological disorders. The history of animal models of iron metabolism misregulation is also discussed followed by a comparison of three patients with a newly discovered neurodegenerative disorder caused by mutations in iron regulatory protein 2.
铁平衡失调与各种神经紊乱的关系日益受到关注。本综述介绍了目前对中枢神经系统中铁代谢的认识，探讨了在神经退行性、神经发育和神经心理障碍等各种疾病状态下铁蓄积和缺乏的后果。文中还讨论了铁代谢失调动物模型的历史，并比较了三种新发现的由铁调节蛋白 2 突变引起的神经退行性疾病患者。
