• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

LncRNA 通过增强表达促进肌肉肥大和快肌纤维转化。

LncRNA Promotes Muscle Hypertrophy and Fast-Twitch Fiber Transformation via Enhancing Expression.

机构信息

Department of Animal Genetics, Breeding and Reproduction, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.

Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou 510642, China.

出版信息

Int J Mol Sci. 2022 Apr 19;23(9):4510. doi: 10.3390/ijms23094510.

DOI:10.3390/ijms23094510
PMID:35562902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9105468/
Abstract

Long noncoding RNA (lncRNA) plays a crucial part in all kinds of life activities, especially in myogenesis. (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily d, member 3) is a member of the SWI/SNF protein complex and was reported to be required for cell proliferation and myoblast differentiation. In this study, we identified a new lncRNA named (), which strongly regulated the development of myogenesis by improving the expression of (). We overexpressed and knockdown the expression of and to investigate their function on myoblast proliferation and differentiation. Cell experiments proved that and promoted myoblast proliferation through the pathway and improved differentiation of differentiated myoblasts through the pathway. Moreover, they upregulated the fast-twitch fiber-related genes and downregulated the slow-twitch fiber-related genes, which indicated that they facilitated the slow-twitch fiber to transform into the fast-twitch fiber. The animals' experiments supported the results above, demonstrating that could induce muscle hypertrophy and fast-twitch fiber transformation. In conclusion, can improve the expression of , thus inducing muscle hypertrophy. In addition, can facilitate slow-twitch fibers to transform into fast-twitch fibers.

摘要

长链非编码 RNA（lncRNA）在各种生命活动中起着至关重要的作用，尤其是在肌发生中。（SWI/SNF 相关，基质相关，肌动蛋白依赖的染色质调节剂，亚家族 d，成员 3）是 SWI/SNF 蛋白复合物的成员，据报道其对于细胞增殖和肌母细胞分化是必需的。在本研究中，我们鉴定了一个新的 lncRNA，命名为（），它通过提高（）的表达强烈调节肌发生的发育。我们过表达和敲低了和的表达，以研究它们对肌母细胞增殖和分化的功能。细胞实验证明，和通过（）途径促进肌母细胞增殖，并通过（）途径改善分化的肌母细胞的分化。此外，它们上调快肌纤维相关基因，下调慢肌纤维相关基因，这表明它们促进了慢肌纤维向快肌纤维的转化。动物实验支持了上述结果，表明可以诱导肌肉肥大和快肌纤维转化。总之，能够提高的表达，从而诱导肌肉肥大。此外，它可以促进慢肌纤维向快肌纤维转化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7653/9105468/9d7276d0969d/ijms-23-04510-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7653/9105468/78aeead28a73/ijms-23-04510-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7653/9105468/634a7db728c6/ijms-23-04510-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7653/9105468/7f363febba25/ijms-23-04510-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7653/9105468/401045202d5e/ijms-23-04510-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7653/9105468/233105769e83/ijms-23-04510-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7653/9105468/3992fb2f2400/ijms-23-04510-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7653/9105468/6a06ce72e197/ijms-23-04510-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7653/9105468/231dc9954193/ijms-23-04510-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7653/9105468/9d7276d0969d/ijms-23-04510-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7653/9105468/78aeead28a73/ijms-23-04510-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7653/9105468/634a7db728c6/ijms-23-04510-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7653/9105468/7f363febba25/ijms-23-04510-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7653/9105468/401045202d5e/ijms-23-04510-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7653/9105468/233105769e83/ijms-23-04510-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7653/9105468/3992fb2f2400/ijms-23-04510-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7653/9105468/6a06ce72e197/ijms-23-04510-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7653/9105468/231dc9954193/ijms-23-04510-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7653/9105468/9d7276d0969d/ijms-23-04510-g009.jpg

相似文献

1
LncRNA Promotes Muscle Hypertrophy and Fast-Twitch Fiber Transformation via Enhancing Expression.LncRNA 通过增强表达促进肌肉肥大和快肌纤维转化。
Int J Mol Sci. 2022 Apr 19;23(9):4510. doi: 10.3390/ijms23094510.
2
LncRNA-TBP mediates TATA-binding protein recruitment to regulate myogenesis and induce slow-twitch myofibers.LncRNA-TBP 介导 TATA 结合蛋白募集以调节成肌作用并诱导慢收缩肌纤维。
Cell Commun Signal. 2023 Jan 12;21(1):7. doi: 10.1186/s12964-022-01001-3.
3
MicroRNA-351-5p mediates skeletal myogenesis by directly targeting lactamase-β and is regulated by lnc-mg.miR-351-5p 通过直接靶向β-内酰胺酶调控 lnc-mg 来介导成肌分化
FASEB J. 2019 Feb;33(2):1911-1926. doi: 10.1096/fj.201701394RRR. Epub 2018 Sep 14.
4
MYH1G-AS is a chromatin-associated lncRNA that regulates skeletal muscle development in chicken.MYH1G-AS 是一种与染色质相关的 lncRNA，可调节鸡的骨骼肌发育。
Cell Mol Biol Lett. 2024 Jan 4;29(1):9. doi: 10.1186/s11658-023-00525-x.
5
lncRNA UCA1 promotes tumor progression by targeting SMARCD3 in cervical cancer.长链非编码 RNA UCA1 通过靶向宫颈癌中的 SMARCD3 促进肿瘤进展。
Mol Carcinog. 2024 Mar;63(3):384-399. doi: 10.1002/mc.23659. Epub 2023 Dec 20.
6
The exercise-induced long noncoding RNA promotes fast-twitch myogenesis in aging.运动诱导的长链非编码RNA促进衰老过程中的快肌生成。
Sci Transl Med. 2021 Dec 8;13(623):eabc7367. doi: 10.1126/scitranslmed.abc7367.
7
COPS3 AS lncRNA enhances myogenic differentiation and maintains fast-type myotube phenotype.COPS3 AS lncRNA 增强成肌分化并维持快型肌管表型。
Cell Signal. 2022 Jul;95:110341. doi: 10.1016/j.cellsig.2022.110341. Epub 2022 Apr 28.
8
Smarcd3 regulates the timing of zebrafish myogenesis onset.Smarcd3调控斑马鱼肌肉发生起始的时间。
J Biol Chem. 2008 Feb 8;283(6):3529-3536. doi: 10.1074/jbc.M708594200. Epub 2007 Dec 3.
9
lncRNA promotes proliferation and suppresses differentiation of myoblasts in skeletal muscle development by attenuating the function of miR-30c.lncRNA 通过削弱 miR-30c 的功能促进骨骼肌发育中的成肌细胞增殖和抑制分化。
FASEB J. 2018 Jan;32(1):377-389. doi: 10.1096/fj.201700560RR. Epub 2017 Sep 13.
10
Lnc-ORA interacts with microRNA-532-3p and IGF2BP2 to inhibit skeletal muscle myogenesis.Lnc-ORA 通过与 microRNA-532-3p 和 IGF2BP2 相互作用抑制骨骼肌成肌分化。
J Biol Chem. 2021 Jan-Jun;296:100376. doi: 10.1016/j.jbc.2021.100376. Epub 2021 Feb 4.

引用本文的文献

1
LncEDCH1 g.1703613 T>C regulates chicken carcass traits by targeting miR-196-2-3p.长链非编码 RNA EDCH1 g.1703613 T>C 通过靶向 miR-196-2-3p 调控鸡体尺性状。
Poult Sci. 2024 Mar;103(3):103412. doi: 10.1016/j.psj.2023.103412. Epub 2023 Dec 29.
2
Exploring the association between fat-related traits in chickens and the RGS16 gene: insights from polymorphism and functional validation analysis.探索鸡脂肪相关性状与RGS16基因之间的关联：来自多态性和功能验证分析的见解。
Front Vet Sci. 2023 May 10;10:1180797. doi: 10.3389/fvets.2023.1180797. eCollection 2023.
3
The Functional Role of Long Non-Coding RNA in Myogenesis and Skeletal Muscle Atrophy.

本文引用的文献

1
CircRILPL1 promotes muscle proliferation and differentiation via binding miR-145 to activate IGF1R/PI3K/AKT pathway.环状 RNA RILPL1 通过结合 miR-145 激活 IGF1R/PI3K/AKT 通路促进肌肉增殖和分化。
Cell Death Dis. 2021 Feb 1;12(2):142. doi: 10.1038/s41419-021-03419-y.
2
Histopathological changes and oxidative damage in type I and type II muscle fibers in rats undergoing paradoxical sleep deprivation.I 型和 II 型肌纤维在经历矛盾性睡眠剥夺的大鼠中的组织病理学变化和氧化损伤。
Cell Signal. 2021 May;81:109939. doi: 10.1016/j.cellsig.2021.109939. Epub 2021 Jan 30.
3
Long noncoding RNA suppresses production-mediated muscle atrophy via nonsense-mediated mRNA decay.
长链非编码 RNA 在成肌作用和骨骼肌萎缩中的功能作用。
Cells. 2022 Jul 25;11(15):2291. doi: 10.3390/cells11152291.
长链非编码RNA通过无义介导的mRNA降解抑制蛋白生成介导的肌肉萎缩。
Mol Ther Nucleic Acids. 2020 Dec 10;23:512-526. doi: 10.1016/j.omtn.2020.12.003. eCollection 2021 Mar 5.
4
The SWI/SNF subunit SMARCD3 regulates cell cycle progression and predicts survival outcome in ER+ breast cancer.SWI/SNF亚基SMARCD3调节细胞周期进程并预测雌激素受体阳性乳腺癌的生存结果。
Breast Cancer Res Treat. 2021 Feb;185(3):601-614. doi: 10.1007/s10549-020-05997-5. Epub 2020 Nov 12.
5
SMARCD3 is a potential prognostic marker and therapeutic target in CAFs.SMARCD3 是 CAFs 中的一个潜在的预后标志物和治疗靶点。
Aging (Albany NY). 2020 Oct 28;12(20):20835-20861. doi: 10.18632/aging.104102.
6
A circular RNA derived from DAB1 promotes cell proliferation and osteogenic differentiation of BMSCs via RBPJ/DAB1 axis.环状 RNA 来源于 DAB1 通过 RBPJ/DAB1 轴促进 BMSCs 的增殖和成骨分化。
Cell Death Dis. 2020 May 15;11(5):372. doi: 10.1038/s41419-020-2572-3.
7
LncIRS1 controls muscle atrophy via sponging miR-15 family to activate IGF1-PI3K/AKT pathway.长链非编码 RNA IRS1 通过海绵吸附 miR-15 家族来激活 IGF1-PI3K/AKT 通路，从而控制肌肉萎缩。
J Cachexia Sarcopenia Muscle. 2019 Apr;10(2):391-410. doi: 10.1002/jcsm.12374. Epub 2019 Jan 30.
8
Intensive Glucose Control Reduces the Risk Effect of , and Genetic Variation on Diabetic Vascular Complications.强化血糖控制降低了、及基因变异对糖尿病血管并发症的风险影响。 你提供的原文中“Intensive Glucose Control Reduces the Risk Effect of, and Genetic Variation on Diabetic Vascular Complications.”似乎有部分内容缺失或表述不完整，翻译出来可能会有些费解。
Front Pharmacol. 2018 Dec 11;9:1422. doi: 10.3389/fphar.2018.01422. eCollection 2018.
9
lncRNA-Six1 Is a Target of miR-1611 that Functions as a ceRNA to Regulate Six1 Protein Expression and Fiber Type Switching in Chicken Myogenesis.长链非编码RNA-Six1是miR-1611的靶标，其作为竞争性内源RNA在鸡肌肉生成过程中调节Six1蛋白表达和纤维类型转换。
Cells. 2018 Dec 4;7(12):243. doi: 10.3390/cells7120243.
10
Long Noncoding RNA lncMUMA Reverses Established Skeletal Muscle Atrophy following Mechanical Unloading.长链非编码 RNA lncMUMA 逆转机械去负荷后稳定的骨骼肌萎缩。
Mol Ther. 2018 Nov 7;26(11):2669-2680. doi: 10.1016/j.ymthe.2018.09.014. Epub 2018 Oct 25.