小分子 GTP 酶及其调节因子：斑马鱼血管发育的主要途径。

Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan.

Department of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

Int J Mol Sci. 2022 Apr 30;23(9):4991. doi: 10.3390/ijms23094991.

Members of the Ras superfamily have been found to perform several functions leading to the development of eukaryotes. These small GTPases are divided into five major subfamilies, and their regulators can "turn on" and "turn off" signals. Recent studies have shown that this superfamily of proteins has various roles in the process of vascular development, such as vasculogenesis and angiogenesis. Here, we discuss the role of these subfamilies in the development of the vascular system in zebrafish.

Ras 超家族的成员被发现具有多种功能，这些功能导致了真核生物的发展。这些小分子 GTP 酶分为五个主要亚家族，其调节剂可以“开启”和“关闭”信号。最近的研究表明，这个蛋白质超家族在血管发育过程中发挥了多种作用，如血管发生和血管生成。在这里，我们讨论了这些亚家族在斑马鱼血管系统发育中的作用。