MicroRNAs 作为吞噬作用的调节因子。
MicroRNAs as Regulators of Phagocytosis.
机构信息
Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Banacha 1a, 02-097 Warsaw, Poland.
Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Żwirki i Wigury 63a, 02-091 Warsaw, Poland.
出版信息
Cells. 2022 Apr 19;11(9):1380. doi: 10.3390/cells11091380.
MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression and thus act as important regulators of cellular phenotype and function. As their expression may be dysregulated in numerous diseases, they are of interest as biomarkers. What is more, attempts of modulation of some microRNAs for therapeutic reasons have been undertaken. In this review, we discuss the current knowledge regarding the influence of microRNAs on phagocytosis, which may be exerted on different levels, such as through macrophages polarization, phagosome maturation, reactive oxygen species production and cytokines synthesis. This phenomenon plays an important role in numerous pathological conditions.
微小 RNA（miRNAs）是短的非编码 RNA，可调节基因表达，因此作为细胞表型和功能的重要调节剂。由于它们的表达可能在许多疾病中失调，因此它们作为生物标志物受到关注。此外，还尝试了出于治疗目的调节某些 microRNAs。在这篇综述中，我们讨论了 microRNAs 对吞噬作用的影响的现有知识，这种影响可能在不同水平上发挥作用，例如通过巨噬细胞极化、吞噬体成熟、活性氧物质产生和细胞因子合成。这种现象在许多病理条件下起着重要作用。
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