Wu Haoming, Wang Yang, Li Huiying, Meng Lu, Zheng Nan, Wang Jiaqi
State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Laboratory of Quality and Safety Risk Assessment for Dairy Products of Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Foods. 2022 Apr 21;11(9):1212. doi: 10.3390/foods11091212.
Alkaline phosphatase (ALP) is abundant in raw milk. Because of its high heat resistance, ALP negative is used as an indicator of successful sterilization. However, pasteurized milk loses its immune protection against allergy. Clinically, ALP is also used as an indicator of organ diseases. When the activity of ALP in blood increases, it is considered that diseases occur in viscera and organs. Oral administration or injecting ALP will not cause harm to the body and has a variety of probiotic effects. For infants with low immunity, ALP intake is a good prebiotic for protecting the infant's intestine from potential pathogenic bacteria. In addition, ALP has a variety of probiotic effects for any age group, including prevention and treatment intestinal diseases, allergies, hepatitis, acute kidney injury (AKI), diabetes, and even the prevention of aging. The prebiotic effects of alkaline phosphatase on the health of infants and consumers and the content of ALP in different mammalian raw milk are summarized. The review calls on consumers and manufacturers to pay more attention to ALP, especially for infants with incomplete immune development. ALP supplementation is conducive to the healthy growth of infants.
碱性磷酸酶（ALP）在生牛奶中含量丰富。由于其具有较高的耐热性，ALP呈阴性被用作成功灭菌的指标。然而，巴氏杀菌牛奶会失去其对过敏的免疫保护作用。临床上，ALP也被用作器官疾病的指标。当血液中ALP的活性增加时，被认为内脏和器官发生了疾病。口服或注射ALP不会对身体造成伤害，并且具有多种益生元效应。对于免疫力低下的婴儿，摄入ALP是一种很好的益生元，可保护婴儿肠道免受潜在病原菌的侵害。此外，ALP对任何年龄段的人群都有多种益生元效应，包括预防和治疗肠道疾病、过敏、肝炎、急性肾损伤（AKI）、糖尿病，甚至预防衰老。总结了碱性磷酸酶对婴儿和消费者健康的益生元效应以及不同哺乳动物生牛奶中ALP的含量。该综述呼吁消费者和制造商更多地关注ALP，特别是对于免疫发育不完全的婴儿。补充ALP有利于婴儿的健康成长。
