Community Care Research Center, Health Insurance Research Institute, National Health Insurance Service, Wonju 26464, Korea.
College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, Korea.
Int J Environ Res Public Health. 2022 Apr 19;19(9):4941. doi: 10.3390/ijerph19094941.
Little is known about the risk of hypertension and type 2 diabetes in relation to changes in frequency and amount of alcohol consumption. This study investigated associations between changes in alcohol consumption and the risk of both conditions. This study included 96,129 individuals without hypertension and/or diabetes mellitus aged ≥ 20 years between 2006 and 2008, with follow-up until 31 December 2015. This study identified 29,043 and 18,784 incident cases of hypertension and type 2 diabetes, respectively, during an average follow-up period of 6.2 ± 2.6 and 6.9 ± 1.9 years. This study measured changes in frequency and amount of alcohol consumption using standardized self-administered questionnaires over approximately 2 years. Hazard ratio (HR) and 95% confidence interval (CI) were calculated for the respective risks of the two conditions. Repeated occasional or frequent binge drinking was associated with an increased risk of hypertension (HR: 1.16 or 1.32; 95% CI: 1.11, 1.21 or 1.16, 1.51) and type 2 diabetes (HR: 1.14 or 1.36; 95% CI: 1.09, 1.20 or 1.17, 1.58) compared with continuous nondrinking. Reductions as well as increases in frequency of alcohol consumption among binge drinkers were associated with higher hypertension (HR: 1.29 or 1.30; 95% CI: 1.11, 1.49 or 1.13, 1.49) and type 2 diabetes (HR: 1.26 or 1.56; 95% CI: 1.06, 1.49 or 1.34, 1.81) risk. This study demonstrated that repeated binge drinking, even with a reduction of weekly alcohol consumption frequency, was associated with a higher risk of hypertension and type 2 diabetes.
关于饮酒频率和量的变化与高血压和 2 型糖尿病风险之间的关系，人们知之甚少。本研究调查了饮酒变化与这两种疾病风险之间的关联。本研究纳入了 96129 名年龄≥20 岁、2006 年至 2008 年期间无高血压和/或糖尿病的个体，随访至 2015 年 12 月 31 日。在平均 6.2±2.6 年和 6.9±1.9 年的随访期间，分别确定了 29043 例和 18784 例高血压和 2 型糖尿病新发病例。本研究使用标准化的自我管理问卷大约 2 年测量了饮酒频率和量的变化。计算了相应两种疾病风险的风险比（HR）和 95%置信区间（CI）。反复偶尔或频繁 binge drinking 与高血压（HR：1.16 或 1.32；95%CI：1.11，1.21 或 1.16，1.51）和 2 型糖尿病（HR：1.14 或 1.36；95%CI：1.09，1.20 或 1.17，1.58）风险增加相关，与持续不饮酒相比。 binge drinkers 饮酒频率减少和增加与高血压（HR：1.29 或 1.30；95%CI：1.11，1.49 或 1.13，1.49）和 2 型糖尿病（HR：1.26 或 1.56；95%CI：1.06，1.49 或 1.34，1.81）风险增加相关。本研究表明，反复 binge drinking，即使每周饮酒频率减少，也与高血压和 2 型糖尿病风险增加相关。
