the Department of Preventive Medicine and Public Health, College of Medicine, Yonsei University, Seoul, Korea.
Stroke. 2010 Oct;41(10):2157-62. doi: 10.1161/STROKEAHA.110.586347. Epub 2010 Aug 19.
The purpose of this study was to examine combined effects of hypertension and binge drinking on the risk of mortality from cardiovascular disease in Koreans.
This study followed a cohort of 6100 residents in Kangwha County, aged ≥55 years as of March 1985, for cardiovascular mortality for 20.8 years up to December 31, 2005. We calculated hazard ratios (HRs) for cardiovascular mortality by blood pressure and binge drinking habits using the Cox proportional hazard model. Binge drinkers and heavy binge drinkers were defined as having ≥6 drinks on 1 occasion and ≥12 drinks on 1 occasion.
After adjusting for total alcohol consumption, male heavy binge drinkers with Grade 3 hypertension had a 12-fold increased risk of cardiovascular mortality (HR, 12.7; 95% CI, 3.47 to 46.5), whereas male binge drinkers with Grade 3 hypertension had a 4-fold increased risk of cardiovascular mortality (HR, 4.41; 95% CI, 1.38 to 14.1) when compared with nondrinkers with normal blood pressure. However, in considering separate effects of heavy binge drinking and hypertension on the risk of cardiovascular mortality, HRs were rather low (HR of heavy binge drinkers, 1.88, 1.10 to 3.20; HR of hypertensives, 2.00, 1.70 to 2.35) compared with nondrinkers with normal blood pressure.
Binge drinkers and heavy binge drinkers with Grade 3 hypertension showed a marked increase in cardiovascular mortality risk. Even after adjusting for total alcohol consumption, the former revealed 4.41 and the latter indicated 12.7 of HR for the risk of cardiovascular mortality.
本研究旨在探讨高血压和 binge drinking 对韩国人心血管疾病死亡率的综合影响。
本研究对 1985 年 3 月年满 55 岁的 Kangwha 县 6100 名居民进行了随访，随访期为 20.8 年，直至 2005 年 12 月 31 日。我们使用 Cox 比例风险模型，根据血压和 binge drinking 习惯计算心血管死亡率的危险比（HR）。 binge drinker 和重度 binge drinker 的定义分别为单次饮酒≥6 杯和≥12 杯。
在调整总酒精摄入量后，男性重度 binge drinker 且伴有 3 级高血压的心血管死亡率风险增加 12 倍（HR，12.7；95%CI，3.47 至 46.5），而男性 binge drinker 且伴有 3 级高血压的心血管死亡率风险增加 4 倍（HR，4.41；95%CI，1.38 至 14.1），与血压正常的不饮酒者相比。然而，在考虑重度 binge drinking 和高血压对心血管死亡率风险的单独影响时，HR 相对较低（重度 binge drinker 的 HR，1.88，1.10 至 3.20；高血压患者的 HR，2.00，1.70 至 2.35），与血压正常的不饮酒者相比。
伴有 3 级高血压的 binge drinker 和重度 binge drinker 的心血管死亡率风险显著增加。即使在调整总酒精摄入量后，前者的心血管死亡率风险 HR 为 4.41，后者的 HR 为 12.7。
