Jones R S, Heinemann U
Exp Brain Res. 1987;65(3):676-80. doi: 10.1007/BF00235992.
The complex EPSP-IPSP response of CA1 pyramidal cells to orthodromic activation of Schaffer collaterals-commissural afferent fibres was monitored during washout of Ca from hippocampal slices. The IPSP was clearly abolished before the EPSP and this occurred when the extracellular Ca([Ca2+]o) had fallen to between 1.03 and 0.7 mM. The loss of the IPSP was usually associated with a temporary increase in size of the EPSP and sometimes a membrane depolarization and the appearance of spontaneous activity. As [Ca2+]o fell further these effects were reversed and eventually the EPSP was abolished when [Ca2+]o had reached between 0.78 and 0.26 mM.
在从海马切片中洗脱钙的过程中，监测了CA1锥体细胞对Schaffer侧支-联合传入纤维的正向激活的复杂兴奋性突触后电位（EPSP）-抑制性突触后电位（IPSP）反应。IPSP在EPSP之前明显消失，当细胞外钙（[Ca2+]o）降至1.03至0.7 mM之间时就会发生这种情况。IPSP的消失通常与EPSP大小的暂时增加有关，有时还与膜去极化和自发活动的出现有关。随着[Ca2+]o进一步下降，这些效应会逆转，最终当[Ca2+]o达到0.78至0.26 mM之间时，EPSP消失。
