State Key Laboratory of Resources and Environmental Information System, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China.
College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China.
Int J Environ Res Public Health. 2022 May 9;19(9):5752. doi: 10.3390/ijerph19095752.
Although significant correlations have been observed between air pollutants and the development of pulmonary tuberculosis (PTB) in many developed countries, data are scarce for developing and highly polluted regions.
A combined Poisson generalized linear regression-distributed lag nonlinear model was used to determine the associations between long-term exposure (2005-2017) to air pollutants and the risk of PTB in the Beijing-Tianjin-Hebei region.
The monthly PTB cases exhibited a fluctuating downward trend. For each 10 μg/m increase in concentration, the maximum lag-specific risk and cumulative relative risk (RR) were 1.011 (95% confidence interval (CI): 1.0091.012, lag: 3 months) and 1.042 (1.036-1.048, 5 months) for PM, and 1.023 (1.015-1.031, 0 months) and 1.041 (1.026-1.055, 2 months) for NO. The risk of PTB was negatively correlated with O exposure, and the minimum lag-specific risk and cumulative RR were 0.991 (95% CI: 0.987-0.994, lag: 0 months) and 0.974 (0.968-0.981, 4 months), respectively. No age-dependent effects were observed.
Our results revealed potential associations between outdoor exposure to PM, NO, and O and the risk of PTB. Further research should explore the corresponding interactions and potential mechanisms.
尽管在许多发达国家已经观察到空气污染物与肺结核（PTB）发展之间存在显著相关性，但在发展中国家和污染严重的地区，相关数据仍然匮乏。
采用泊松广义线性回归-分布滞后非线性模型，来确定北京-天津-河北地区长期暴露（2005-2017 年）于空气污染物与 PTB 风险之间的关联。
每月 PTB 病例呈波动下降趋势。每增加 10μg/m3 的浓度，最大滞后特定风险和累积相对风险（RR）分别为 1.011（95%置信区间（CI）：1.0091.012，滞后：3 个月）和 1.042（1.036-1.048，5 个月）的 PM，和 1.023（1.015-1.031，0 个月）和 1.041（1.026-1.055，2 个月）的 NO。PTB 的发病风险与 O3 暴露呈负相关，最小滞后特定风险和累积 RR 分别为 0.991（95%CI：0.987-0.994，滞后：0 个月）和 0.974（0.968-0.981，4 个月）。未观察到年龄依赖性效应。
我们的研究结果揭示了户外 PM、NO 和 O3 暴露与 PTB 发病风险之间存在潜在关联。进一步的研究应探讨相应的相互作用和潜在机制。
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