Joerger Markus, Metaxas Yannis, Zaman Khalil, Michielin Olivier, Mach Nicolas, Bettini Adrienne, Schmitt Andreas M, Cantoni Nathan, Caspar Clemens B, Stettler Sonja, Malval Roma, Pless Miklos, Britschgi Christian, Renner Christoph, Koeberle Dieter, Schulz Jessica D, Kopp Christoph, Hayoz Stefanie, Stathis Anastasios, von Moos Roger
Department of Oncology, Cantonal Hospital, 9007 St. Gallen, Switzerland.
Department of Medical Oncology, Cantonal Hospital, 8596 Muensterlingen, Switzerland.
Cancers (Basel). 2022 Apr 27;14(9):2191. doi: 10.3390/cancers14092191.
Purpose: These are the final results of a national registry on cancer patients with COVID-19 in Switzerland. Methods: We collected data on symptomatic COVID-19-infected cancer patients from 23 Swiss sites over a one-year period starting on 1 March 2020. The main objective was to assess the outcome (i.e., mortality, rate of hospitalization, ICU admission) of COVID-19 infection in cancer patients; the main secondary objective was to define prognostic factors. Results: From 455 patients included, 205 patients (45%) had non-curative disease, 241 patients (53%) were hospitalized for COVID-19, 213 (47%) required oxygen, 43 (9%) invasive ventilation and 62 (14%) were admitted to the ICU. Death from COVID-19 infection occurred in 98 patients, resulting in a mortality rate of 21.5%. Age ≥65 years versus <65 years (OR 3.14, p = 0.003), non-curative versus curative disease (OR 2.42, p = 0.012), ICU admission (OR 4.45, p < 0.001) and oxygen requirement (OR 20.28, p < 0.001) were independently associated with increased mortality. Conclusions: We confirmed high COVID-19 severity and mortality in real-world cancer patients during the first and second wave of the pandemic in a country with a decentralized, high-quality, universal-access health care system. COVID-19-associated mortality was particularly high for those of older age in a non-curative disease setting, requiring oxygen or ICU care.
这些是瑞士一项关于新冠肺炎癌症患者的全国性登记研究的最终结果。方法：我们收集了2020年3月1日起为期一年的23个瑞士研究点的有症状的新冠肺炎感染癌症患者的数据。主要目的是评估癌症患者中新冠肺炎感染的结局（即死亡率、住院率、重症监护病房（ICU）收治率）；主要次要目的是确定预后因素。结果：在纳入的455例患者中，205例（45%）患有不可治愈性疾病，241例（53%）因新冠肺炎住院，213例（47%）需要吸氧，43例（9%）需要有创通气，62例（14%）入住ICU。98例患者死于新冠肺炎感染，死亡率为21.5%。年龄≥65岁与<65岁（比值比（OR）3.14，p = 0.003）、不可治愈性疾病与可治愈性疾病（OR 2.42，p = 0.012）、入住ICU（OR 4.45，p < 0.001）和需要吸氧（OR 20.28，p < 0.001）与死亡率增加独立相关。结论：在一个拥有分散化、高质量、全民可及医疗保健系统的国家，我们证实在疫情第一波和第二波期间，现实世界中的癌症患者新冠肺炎病情严重程度高且死亡率高。在不可治愈性疾病情况下，年龄较大、需要吸氧或ICU治疗的患者与新冠肺炎相关的死亡率尤其高。
