Le Chapelain Ophélie, Ho-Tin-Noé Benoît
Laboratory of Vascular Translational Science, U1148 Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Cité, F-75006 Paris, France.
Cancers (Basel). 2022 Apr 27;14(9):2192. doi: 10.3390/cancers14092192.
The tumor microenvironment (TME) has gained considerable interest because of its decisive impact on cancer progression, response to treatment, and disease recurrence. The TME can favor the proliferation, dissemination, and immune evasion of cancer cells. Likewise, there is accumulating evidence that intratumoral platelets could favor the development and aggressiveness of solid tumors, notably by influencing tumor cell phenotype and shaping the vascular and immune TME components. Yet, in contrast to other tumor-associated cell types like macrophages and fibroblasts, platelets are still often overlooked as components of the TME. This might be due, in part, to a deficit in investigating and reporting the presence of platelets in the TME and its relationships with cancer characteristics. This review summarizes available evidence from clinical and animal studies supporting the notion that tumor-associated platelets are not incidental bystanders but instead integral and active components of the TME. A particular emphasis is given to the description of intratumoral platelets, as well as to the functional consequences and possible mechanisms of intratumoral platelet accumulation.
肿瘤微环境（TME）因其对癌症进展、治疗反应和疾病复发具有决定性影响而备受关注。肿瘤微环境可促进癌细胞的增殖、扩散和免疫逃逸。同样，越来越多的证据表明，肿瘤内血小板可能促进实体瘤的发展和侵袭性，特别是通过影响肿瘤细胞表型以及塑造血管和免疫肿瘤微环境成分。然而，与巨噬细胞和成纤维细胞等其他肿瘤相关细胞类型相比，血小板作为肿瘤微环境的组成部分仍常常被忽视。这可能部分归因于在研究和报告肿瘤微环境中血小板的存在及其与癌症特征的关系方面存在不足。本综述总结了临床和动物研究中的现有证据，支持肿瘤相关血小板并非偶然旁观者，而是肿瘤微环境不可或缺的活跃组成部分这一观点。特别强调了肿瘤内血小板的描述，以及肿瘤内血小板积聚的功能后果和可能机制。
