肿瘤微环境中的CXCR4/CXCL12活性及其对肿瘤免疫治疗的意义
CXCR4/CXCL12 Activities in the Tumor Microenvironment and Implications for Tumor Immunotherapy.
作者信息
Mezzapelle Rosanna, Leo Manuela, Caprioglio Francesca, Colley Liam S, Lamarca Andrea, Sabatino Lina, Colantuoni Vittorio, Crippa Massimo P, Bianchi Marco E
机构信息
School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Division of Genetics and Cell Biology, IRCCS San Raffaele Hospital, 20232 Milan, Italy.
出版信息
Cancers (Basel). 2022 May 6;14(9):2314. doi: 10.3390/cancers14092314.
CXCR4 is a G-Protein coupled receptor that is expressed nearly ubiquitously and is known to control cell migration via its interaction with CXCL12, the most ancient chemokine. The functions of CXCR4/CXCL12 extend beyond cell migration and involve the recognition and disposal of unhealthy or tumor cells. The CXCR4/CXCL12 axis plays a relevant role in shaping the tumor microenvironment (TME), mainly towards dampening immune responses. Notably, CXCR4/CXCL12 cross-signal via the T and B cell receptors (TCR and BCR) and co-internalize with CD47, promoting tumor cell phagocytosis by macrophages in an anti-tumor immune process called ImmunoGenic Surrender (IGS). These specific activities in shaping the immune response might be exploited to improve current immunotherapies.
CXCR4是一种G蛋白偶联受体，几乎在所有地方都有表达，已知它通过与最古老的趋化因子CXCL12相互作用来控制细胞迁移。CXCR4/CXCL12的功能不仅限于细胞迁移，还涉及对不健康或肿瘤细胞的识别和清除。CXCR4/CXCL12轴在塑造肿瘤微环境（TME）中发挥着相关作用，主要是抑制免疫反应。值得注意的是，CXCR4/CXCL12通过T细胞和B细胞受体（TCR和BCR）进行交叉信号传递，并与CD47共同内化，在一种称为免疫原性投降（IGS）的抗肿瘤免疫过程中促进巨噬细胞对肿瘤细胞的吞噬作用。这些在塑造免疫反应中的特定活动可能被用于改进当前的免疫疗法。
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