Van Meerbeeck Jan P, O'Dowd Emma, Ward Brian, Van Schil Paul, Snoeckx Annemiek
Department of Thoracic Oncology, Antwerp University and Antwerp University Hospital, 2650 Edegem, Belgium.
Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UK.
Cancers (Basel). 2022 May 9;14(9):2343. doi: 10.3390/cancers14092343.
Randomized-controlled trials have shown clear evidence that lung cancer screening with low-dose CT in a high-risk population of current or former smokers can significantly reduce lung-cancer-specific mortality by an inversion of stage distribution at diagnosis. This paper will review areas in which there is good or emerging evidence and areas which still require investment, research or represent implementation challenges. The implementation of population-based lung cancer screening in Europe is variable and fragmented. A number of European countries seem be on the verge of implementing lung cancer screening, mainly through the implementation of studies or trials. The cost and capacity of CT scanners and radiologists are considered to be the main hurdles for future implementation. Actions by the European Commission, related to its published Europe's Beating Cancer Plan and the proposal to update recommendations on cancer screening, could be an incentive to help speed up its implementation.
随机对照试验已提供明确证据表明，在当前或既往吸烟者的高危人群中采用低剂量CT进行肺癌筛查，可通过逆转诊断时的分期分布显著降低肺癌特异性死亡率。本文将回顾已有充分或新出现证据的领域，以及仍需投入、研究或面临实施挑战的领域。欧洲基于人群的肺癌筛查实施情况参差不齐且碎片化。一些欧洲国家似乎即将实施肺癌筛查，主要是通过开展研究或试验。CT扫描仪和放射科医生的成本及能力被视为未来实施的主要障碍。欧盟委员会根据其发布的《欧洲抗癌计划》以及更新癌症筛查建议的提案所采取的行动，可能会成为推动加快实施的一项激励措施。
