Bordbar Farhad, Mohammadabadi Mohammadreza, Jensen Just, Xu Lingyang, Li Junya, Zhang Lupei
Key Laboratory of Animal Genetics Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Department of Animal Science, Faculty of Agriculture, Shahid Bahonar University of Kerman, Kerman 77951, Iran.
Animals (Basel). 2022 Apr 25;12(9):1103. doi: 10.3390/ani12091103.
Genome-wide association studies are a robust means of identifying candidate genes that regulate economically important traits in farm animals. The aim of this study is to identify single-nucleotide polymorphisms (SNPs) and candidate genes potentially related to carcass depth and hind leg circumference in Simmental beef cattle. We performed Illumina Bovine HD Beadchip (670 k SNPs) and next-generation sequencing (12 million imputed SNPs) analyses of data from 1252 beef cattle, to which we applied a linear mixed model. Using a statistical threshold ( = 0.05/number of SNPs identified) and adopting a false discovery rate (FDR), we identified many putative SNPs on different bovine chromosomes. We identified 12 candidate genes potentially annotated with the markers identified, including and , related to myogenesis and skeletal muscle development. The identification of such genes in Simmental beef cattle will help breeders to understand and improve related traits, such as meat yield.
全基因组关联研究是识别调控家畜经济重要性状的候选基因的有力手段。本研究的目的是鉴定西门塔尔肉牛中与胴体深度和后腿周长潜在相关的单核苷酸多态性（SNP）和候选基因。我们对1252头肉牛的数据进行了Illumina牛HD Beadchip（约67万个SNP）和下一代测序（约1200万个推算SNP）分析，并应用线性混合模型。使用统计阈值（= 0.05/鉴定出的SNP数量）并采用错误发现率（FDR），我们在不同的牛染色体上鉴定出许多推定的SNP。我们鉴定出12个可能与鉴定出的标记相关的候选基因，包括与肌生成和骨骼肌发育相关的 和 。在西门塔尔肉牛中鉴定出此类基因将有助于育种者了解和改善相关性状，如肉产量。
