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高原环境通过AMPK/p38 MAPK/Nrf2-ARE信号通路对藏猪和杜洛克×长白猪×约克夏猪心脏和肝脏氧化状态的影响

Effect of a Plateau Environment on the Oxidation State of the Heart and Liver through AMPK/p38 MAPK/Nrf2-ARE Signaling Pathways in Tibetan and DLY Pigs.

作者信息

Hu Hong, Li Yongxiang, Yang Yuting, Xu Kexing, Yang Lijie, Qiao Shiyan, Pan Hongbin

机构信息

Yunnan Provincial Key Laboratory of Animal Nutrition and Feed Science, Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.

State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.

出版信息

Animals (Basel). 2022 May 9;12(9):1219. doi: 10.3390/ani12091219.

DOI:10.3390/ani12091219
PMID:35565644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9104009/
Abstract

This study evaluated the effect of a plateau environment on the heart and liver oxidation state of Tibetan pigs (TPs) and DLY pigs through analyzing AMPK, p38 MAPK, and Nrf2 signaling pathways. Twelve 120-day-old TPs and twelve 120-day-old DLY pigs were randomly divided into two groups in a plateau environment for three weeks. Exposed to a plateau environment, TPs exhibited a lower (p < 0.05) malondialdehyde level but higher (p < 0.05) glutathione, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and total antioxidant capacity (T-AOC) activities in the liver and heart than those observed in DLY pigs. TPs also showed higher (p < 0.05) mRNA levels of SOD and GSH-Px in the liver and heart compared with those of DLY pigs. The TPs showed higher (p < 0.05) mRNA and protein levels of AMPK and Nrf2 in the liver and heart compared with those of DLY pigs. Furthermore, TPs showed higher (p < 0.05) mRNA and protein levels of p38 MAPK in the heart and higher mRNA levels of p38 MAPK in the liver compared with those of DLY pigs under a plateau environment. In summary, TPs possess a stronger antioxidant capacity in the heart and liver than that of DLY pigs in a plateau environment through AMPK/p38 MAPK/Nrf2-ARE signaling pathways.

摘要

本研究通过分析AMPK、p38 MAPK和Nrf2信号通路，评估了高原环境对藏猪（TPs）和杜洛克×长白×约克夏猪（DLY猪）心脏和肝脏氧化状态的影响。将12头120日龄的藏猪和12头120日龄的DLY猪在高原环境中随机分为两组，为期三周。暴露于高原环境下，藏猪肝脏和心脏中的丙二醛水平较低（p < 0.05），但谷胱甘肽、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）和总抗氧化能力（T-AOC）活性高于DLY猪（p < 0.05）。与DLY猪相比，藏猪肝脏和心脏中SOD和GSH-Px的mRNA水平也更高（p < 0.05）。与DLY猪相比，藏猪肝脏和心脏中AMPK和Nrf2的mRNA和蛋白水平更高（p < 0.05）。此外，在高原环境下，与DLY猪相比，藏猪心脏中p38 MAPK的mRNA和蛋白水平更高，肝脏中p38 MAPK的mRNA水平更高（p < 0.05）。总之，在高原环境中，藏猪通过AMPK/p38 MAPK/Nrf2-ARE信号通路在心脏和肝脏中具有比DLY猪更强的抗氧化能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/707f/9104009/4f879ee5509c/animals-12-01219-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/707f/9104009/f6a871b1f249/animals-12-01219-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/707f/9104009/e833137e0012/animals-12-01219-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/707f/9104009/a2166d5017b0/animals-12-01219-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/707f/9104009/661663452258/animals-12-01219-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/707f/9104009/ac99df8ef1a8/animals-12-01219-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/707f/9104009/4f879ee5509c/animals-12-01219-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/707f/9104009/f6a871b1f249/animals-12-01219-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/707f/9104009/e833137e0012/animals-12-01219-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/707f/9104009/a2166d5017b0/animals-12-01219-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/707f/9104009/661663452258/animals-12-01219-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/707f/9104009/ac99df8ef1a8/animals-12-01219-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/707f/9104009/4f879ee5509c/animals-12-01219-g006.jpg

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