Hong Seulmin, Park Seonkyeong, Lee Jangho, Park Soohyun, Park Jaeho, Lee Yugeon
Food Functionality Research Division, Korea Food Research Institute (KFRI), Wanju-gun, Jeonbuk-do 55365, Republic of Korea.
Department of Food Science and Technology, Chung-Ang University, Anseong, Gyeonggi-do 17546, Republic of Korea.
Nutrients. 2024 Nov 29;16(23):4139. doi: 10.3390/nu16234139.
This study offers promising insights into the anti-obesity potential an edible mushroom valued in Asian cuisine for its nutritional benefits. A hot water extract of (PWE) administered to high-fat diet-induced obese mice over an 8-week period significantly reduced their body weight gain and fat accumulation. PWE not only improved the body weight metrics but also positively influenced the serum lipid profile of obese mice by lowering their total cholesterol and low-density lipoprotein cholesterol levels. In vitro studies using 3T3-L1 adipocytes showed that PWE inhibited adipocyte differentiation and lipid accumulation by downregulating key adipogenic transcription factors, particularly PPARγ and C/EBPα, as well as related lipogenic genes involved in fat synthesis and storage, such as Fabp4, Fasn, and Scd1. Chemical analysis revealed that PWE is rich in polysaccharides, which have been associated with various health benefits, including anti-obesity, anti-diabetic, and anti-cancer properties. These findings suggest that the bioactive compounds in PWE may serve as functional food components that could potentially be applied for the prevention and management of obesity and other metabolic disorders.
本研究为一种在亚洲美食中因其营养价值而备受重视的食用菌的抗肥胖潜力提供了有前景的见解。在为期8周的时间里，将香菇热水提取物（PWE）给予高脂饮食诱导的肥胖小鼠，显著降低了它们的体重增加和脂肪堆积。PWE不仅改善了体重指标，还通过降低肥胖小鼠的总胆固醇和低密度脂蛋白胆固醇水平，对其血清脂质谱产生了积极影响。使用3T3-L1脂肪细胞进行的体外研究表明，PWE通过下调关键的脂肪生成转录因子，特别是PPARγ和C/EBPα，以及参与脂肪合成和储存的相关脂肪生成基因，如Fabp4、Fasn和Scd1，抑制脂肪细胞分化和脂质积累。化学分析表明，PWE富含多糖，多糖与多种健康益处相关，包括抗肥胖、抗糖尿病和抗癌特性。这些发现表明，PWE中的生物活性化合物可能作为功能性食品成分， potentially be applied for the prevention and management of obesity and other metabolic disorders.（此处原文有误，正确的应是“可潜在地应用于肥胖症和其他代谢紊乱的预防和管理”） 可能用于肥胖症和其他代谢紊乱的预防和管理。
