Zhu Hanyu, Hou Tao
College of Life Science, Hengyang Normal University, Hengyang 421000, China.
College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Foods. 2024 Mar 20;13(6):948. doi: 10.3390/foods13060948.
(LH), a great wild endemic fungus, contains rich nutritional components with medicinal properties. The effects of LH on body weight, liver weight, liver injury, blood lipids, and gut microbiota in C57BL/6 mice fed a high-fat diet (HFD) for 8 weeks was examined in this research. Though there was no clear impact on weight loss, the findings indicate that LH treatment effectively decreased liver damage caused by HFD, as well as lowered serum total cholesterol, triacylglycerol, and low-density lipoprotein cholesterol levels. Additionally, it positively influenced gut microbiota to resemble that of mice on a normal diet. In HFD-fed mice, LH markedly boosted the levels of , unclassified , , and unclassified , while reducing the abundance of group and , as well as the ratio of Firmicutes to Bacteroidetes. Further analysis of correlation indicate a possible connection between obesity and gut microbiota. Obesity-related indices show a positive association with unclassified group, , and , while displaying a negative correlation with unclassified , unclassified group, , , unclassified , , and unclassified . The results suggest that LH can help combat obesity and may have the potential to be utilized as a functional food.
LH是一种大型野生特有真菌，含有丰富的具有药用特性的营养成分。本研究考察了LH对高脂饮食（HFD）喂养8周的C57BL/6小鼠体重、肝脏重量、肝损伤、血脂和肠道微生物群的影响。虽然对体重减轻没有明显影响，但研究结果表明，LH治疗可有效降低HFD引起的肝损伤，同时降低血清总胆固醇、三酰甘油和低密度脂蛋白胆固醇水平。此外，它对肠道微生物群有积极影响，使其类似于正常饮食小鼠的肠道微生物群。在HFD喂养的小鼠中，LH显著提高了未分类的、、和未分类的水平，同时降低了组和的丰度，以及厚壁菌门与拟杆菌门的比例。相关性的进一步分析表明肥胖与肠道微生物群之间可能存在联系。肥胖相关指标与未分类的组、和呈正相关，而与未分类的、未分类的组、、、未分类的、和未分类的呈负相关。结果表明，LH有助于对抗肥胖，可能有潜力用作功能性食品。
