Study Program of Chemistry, Faculty of Mathematics and Natural Science, Universitas Pakuan, Bogor 16143, Indonesia.
Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Padjadjaran, Sumedang 45363, Indonesia.
Molecules. 2022 Apr 30;27(9):2861. doi: 10.3390/molecules27092861.
Based on data from The Global Burden of Disease Study in 2016, dental and oral health problems, especially dental caries, are a disease experienced by almost half of the world's population (3.58 billion people). One of the main causes of dental caries is the pathogenesis of . Prevention can be achieved by controlling using an antibacterial agent. The most commonly used antibacterial for the treatment of dental caries is chlorhexidine. However, long-term use of chlorhexidine has been reported to cause resistance and some side effects. Therefore, the discovery of a natural antibacterial agent is an urgent need. A natural antibacterial agent that can be used are herbal medicines derived from medicinal plants. Ruiz and Pav has the potential to be used as a natural antibacterial agent for treating dental and oral health problems. Several studies reported that the leaves of Ruiz and Pav contain secondary metabolites such as essential oils, flavonoids, alkaloids, terpenoids, tannins, and phenolic compounds that are active against . This review summarizes some information about Ruiz and Pav, various isolation methods, bioactivity, bacteria that cause dental caries, biofilm formation mechanism, antibacterial properties, and the antibacterial mechanism of secondary metabolites in Ruiz and Pav.
基于 2016 年全球疾病负担研究的数据，口腔和牙齿健康问题，尤其是龋齿，是全球近一半人口（35.8 亿人）所经历的一种疾病。龋齿的主要病因之一是 的发病机制。可以通过使用抗菌剂来控制 来预防龋齿。治疗龋齿最常用的抗菌剂是洗必泰。然而，长期使用洗必泰已被报道会导致耐药性和一些副作用。因此，急需发现一种天然的抗菌剂。一种可以使用的天然抗菌剂是来源于药用植物的草药。Ruiz 和 Pav 具有成为治疗口腔和牙齿健康问题的天然抗菌剂的潜力。有几项研究报告称，Ruiz 和 Pav 的叶子含有多种次生代谢物，如精油、类黄酮、生物碱、萜类、单宁和酚类化合物，对 具有活性。这篇综述总结了有关 Ruiz 和 Pav 的一些信息，各种分离方法，生物活性，引起龋齿的细菌，生物膜形成机制，抗菌特性以及 Ruiz 和 Pav 次生代谢物的抗菌机制。
