Virgili Gianni, Parravano Mariacristina, Petri Davide, Maurutto Erica, Menchini Francesca, Lanzetta Paolo, Varano Monica, Mariotti Silvio Paolo, Cherubini Antonio, Lucenteforte Ersilia
Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence and AOU Careggi, 50139 Florence, Italy.
IRCCS-Fondazione Bietti, 00198 Rome, Italy.
J Clin Med. 2022 Apr 25;11(9):2412. doi: 10.3390/jcm11092412.
We conducted a systematic review and meta-analysis to investigate whether depression is associated with vision impairment (VI) in population-based studies in adults. MEDLINE and EMBASE were searched, from inception to June 2020. Studies were included if they provided two-by-two data for calculating the OR of association between VI and depression, or crude and/or an adjusted odds ratio (OR) with a corresponding 95% confidence interval (CI) were reported. The proportion of VI and depression was also extracted. ORs were pooled using random-effect models, proportions were pooled using random intercepts logistic regression models. Overall, 29 articles (31 studies) were included: of those, 18 studies used survey data (622,312 participants), 10 used clinical examination data (69,178 participants), and 3 used administrative databases (48,162,290 participants). The proportion of depression (95%CI) was 0.17 (0.13-0.22) overall and 0.27 (0.21-0.33) in VI subjects. The proportion of VI was 0.10 (0.07-0.16) overall and 0.20 (0.13-0.29) in depressed subjects. The association between VI and depression was direct: crude ORs were 1.89 (1.51-2.37) for survey data, 2.17 (1.76-2.67) for clinical examination data, and 3.34 (1.01-11.11) for administrative databases; adjusted ORs were 1.75 (1.34-2.30), 1.59 (1.22-1.96), and 2.47 (0.97-6.33), respectively. In conclusion, VI and depression are prevalent morbidities and should be actively sought when either is identified, especially in older adults.
我们进行了一项系统综述和荟萃分析，以调查在基于人群的成人研究中，抑郁症是否与视力损害（VI）相关。检索了MEDLINE和EMBASE数据库，时间跨度从数据库建立至2020年6月。如果研究提供了用于计算VI与抑郁症关联比值比（OR）的四格表数据，或者报告了粗比值比和/或调整后的比值比（OR）以及相应的95%置信区间（CI），则纳入该研究。还提取了VI和抑郁症的比例。使用随机效应模型合并OR，使用随机截距逻辑回归模型合并比例。总体而言，共纳入29篇文章（31项研究）：其中，18项研究使用调查数据（622,312名参与者），10项使用临床检查数据（69,178名参与者），3项使用行政数据库（48,162,290名参与者）。总体抑郁症比例（95%CI）为0.17（0.13 - 0.22），VI患者中为0.27（0.21 - 0.33）。总体VI比例为0.10（0.07 - 0.16），抑郁症患者中为0.20（0.13 - 0.29）。VI与抑郁症之间的关联是直接的：调查数据的粗OR为1.89（1.51 - 2.37），临床检查数据为2.17（1.76 - 2.67），行政数据库为3.34（1.01 - 11.11）；调整后的OR分别为1.75（1.34 - 2.30）、1.59（1.22 - 1.96）和2.47（0.97 - 6.33）。总之，VI和抑郁症是常见的疾病，当发现其中任何一种疾病时，都应积极筛查另一种疾病，尤其是在老年人中。
