Min Jihee, Kim Ji Young, Choi Ji Yeong, Kong In Deok
Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Korea.
Yonsei Institute of Sports Science and Exercise Medicine (YISSEM), Wonju 26426, Korea.
J Clin Med. 2022 Apr 30;11(9):2527. doi: 10.3390/jcm11092527.
The association between physical activity and telomere length (TL) has been continuously reported. However, the interplay of physical activity and TL among women with breast cancer has not been elucidated. Thus, the purpose of this systematic review was to synthesize the evidence for the association of physical activity with TL in women with breast cancer. Systematic searches were conducted to identify quantified studies using MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Web of Science, and Clinical Trials.gov. Five studies were included in this systematic review. Three of the five studies reported that physical activity has a significant relationship in delaying TL shortening, but others observed no association between physical activity and TL in breast cancer survivors. Although the heterogeneous studies acted as limitations in drawing clear conclusions, physical activity strategies show encouraging impacts in delaying TL shortening. To understand the effects of physical activity on TL shortening in breast cancer survivors, further studies are needed considering the tissue site, treatments for breast cancer, DNA extraction methods, and tools for measuring physical activity.
身体活动与端粒长度（TL）之间的关联已被持续报道。然而，乳腺癌女性中身体活动与端粒长度之间的相互作用尚未阐明。因此，本系统评价的目的是综合乳腺癌女性中身体活动与端粒长度关联的证据。通过检索MEDLINE、EMBASE、Cochrane对照试验中心注册库、科学网和临床试验.gov进行系统检索，以识别量化研究。本系统评价纳入了五项研究。五项研究中的三项报告称，身体活动在延缓端粒长度缩短方面具有显著关系，但其他研究未观察到乳腺癌幸存者的身体活动与端粒长度之间存在关联。尽管这些异质性研究在得出明确结论时存在局限性，但身体活动策略在延缓端粒长度缩短方面显示出令人鼓舞的影响。为了解身体活动对乳腺癌幸存者端粒长度缩短的影响，需要进一步开展研究，考虑组织部位、乳腺癌治疗方法、DNA提取方法以及身体活动测量工具等因素。
