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牙周炎及其他与心肌梗死及其随访相关的危险因素。

Periodontitis and Other Risk Factors Related to Myocardial Infarction and Its Follow-Up.

作者信息

Seoane Tania, Bullon Beatriz, Fernandez-Riejos Patricia, Garcia-Rubira Juan Carlos, Garcia-Gonzalez Nestor, Villar-Calle Pablo, Quiles Jose Luis, Battino Maurizio, Bullon Pedro

机构信息

Department of Cardiology, Lucus Augusi University Hospital, 27003 Lugo, Spain.

Department of Stomatology, Dental School, Universidad de Sevilla, 41009 Sevilla, Spain.

出版信息

J Clin Med. 2022 May 6;11(9):2618. doi: 10.3390/jcm11092618.

Abstract

The main issue in the prevention of myocardial infarction (MI) is to reduce risk factors. Periodontal disease is related to cardiovascular disease and both share risk factors. The purpose of this study is to investigate whether periodontitis can be considered a risk factor for MI and common risk factors in a case-control study and in a prospective follow-up study in patients with MI. The test group (MIG) was made up of 144 males who had MI in the previous 48 h. The control group (CG) was composed of 138 males without MI. Both groups were subdivided according to the presence or absence of stage III and IV of periodontitis. General data; Mediterranean diet and physical activity screening; periodontal data; and biochemical, microbiological and cardiological parameters were recorded. ANOVA, Mann-Whitney U and Kruskal-Wallis statistical tests and binary logistic regression analysis were applied. No differences in anthropometric variables were observed between the four groups. The average weekly exercise hours have a higher value in CG without periodontitis. The number of leukocytes was higher in MIG, the number of monocytes was higher in CG and the number of teeth was lower in MIG with periodontitis. Adherence to the Mediterranean diet was higher in CG. and were higher in CG with periodontitis and in MIG with and without periodontitis. At follow-up, the left ventricular ejection fraction (LVEF) data were better in the non-periodontitis group: 15 patients had Mayor Cardiovascular Adverse Events (MACE), 13 of them had periodontitis and 2 did not show periodontitis. Periodontitis, exercise, diet and smoking are risk factors related to MI. MACE presented in the 'MI follow-up' shows periodontitis, weight, exercise hours and dyslipidemia as risk factors. LVEF follow-up values are preserved in patients without periodontitis. Our data suggest that periodontitis can be considered a risk factor for MI and MACE in the studied population.

摘要

预防心肌梗死(MI)的主要问题是降低风险因素。牙周疾病与心血管疾病相关,且二者具有共同的风险因素。本研究的目的是在一项病例对照研究以及一项针对心肌梗死患者的前瞻性随访研究中,调查牙周炎是否可被视为心肌梗死的风险因素以及常见风险因素。试验组(MIG)由144名在过去48小时内发生心肌梗死的男性组成。对照组(CG)由138名无心肌梗死的男性组成。两组均根据是否存在III期和IV期牙周炎进行细分。记录了一般数据、地中海饮食和身体活动筛查情况、牙周数据以及生化、微生物学和心脏病学参数。应用了方差分析、曼-惠特尼U检验、克鲁斯卡尔-沃利斯统计检验以及二元逻辑回归分析。四组之间在人体测量变量方面未观察到差异。在无牙周炎的对照组中,平均每周运动小时数的值更高。试验组中白细胞数量更高,对照组中单核细胞数量更高,患有牙周炎的试验组中牙齿数量更少。对照组对地中海饮食的依从性更高。在患有牙周炎的对照组以及患有和未患有牙周炎的试验组中,[此处原文缺失两个具体指标]更高。在随访时,非牙周炎组的左心室射血分数(LVEF)数据更好:15名患者发生了主要心血管不良事件(MACE),其中13人患有牙周炎,2人未表现出牙周炎。牙周炎、运动、饮食和吸烟是与心肌梗死相关的风险因素。在“心肌梗死随访”中出现的MACE表明牙周炎、体重、运动小时数和血脂异常是风险因素。无牙周炎患者的LVEF随访值保持良好。我们的数据表明,在研究人群中,牙周炎可被视为心肌梗死和MACE的风险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efec/9101354/9d3497ab2c09/jcm-11-02618-g001.jpg

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