Wang Qunhao, Li Mei, Zheng Zhuo, Niu Yan, Xue Xiaolin, Ao Chenghong, Zhang Wei, Lu Canhui
State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute, Sichuan University, Chengdu 610065, China.
Faculty of Environmental Science & Engineering, Kunming University of Science & Technology, Kunming 650500, China.
Polymers (Basel). 2022 Apr 26;14(9):1748. doi: 10.3390/polym14091748.
Electrospun cellulose nanofiber nonwovens have shown promise in wound dressing owing to the highly interconnected pore structure, high hydrophilicity coupled with other coveted characteristics of biodegradability, biocompatibility and renewability. However, electrospun cellulose wound dressings with loaded drugs for better wound healing have been rarely reported. In this study, a novel wound dressing with a high drug loading capacity and sustained drug release properties was successfully fabricated via electropinning of cellulose followed by polyethylenimine (PEI)-functionalization. Remarkably, the grafted PEI chains on the surface of electrospun cellulose nanofibers provided numerous active amino groups, while the highly porous structure of nonwovens could be well retained after modification, which resulted in enhanced adsorption performance against the anionic drug of sodium salicylate (NaSA). More specifically, when immersed in 100 mg/L NaSA solution for 24 h, the as-prepared cellulose-PEI nonwoven displayed a multilayer adsorption behavior. And at the optimal pH of 3, a high drug loading capacity of 78 mg/g could be achieved, which was 20 times higher than that of pristine electrospun cellulose nonwoven. Furthermore, it was discovered that the NaSA-loaded cellulose-PEI could continuously release the drug for 12 h in simulated body fluid (SBF), indicating the versatility of cellulose-PEI as an advanced wound dressing with drug carrier functionalities.
由于具有高度互连的孔隙结构、高亲水性以及生物可降解性、生物相容性和可再生性等其他令人垂涎的特性，静电纺丝纤维素纳米纤维无纺布在伤口敷料方面显示出了应用前景。然而，关于负载药物以促进更好伤口愈合的静电纺丝纤维素伤口敷料的报道却很少。在本研究中，通过对纤维素进行静电纺丝，然后进行聚乙烯亚胺（PEI）功能化，成功制备了一种具有高载药量和持续药物释放性能的新型伤口敷料。值得注意的是，静电纺丝纤维素纳米纤维表面接枝的PEI链提供了大量活性氨基，同时无纺布的高度多孔结构在改性后仍能得到很好的保留，这导致其对阴离子药物水杨酸钠（NaSA）的吸附性能增强。更具体地说，当将所制备的纤维素-PEI无纺布浸入100 mg/L的NaSA溶液中24小时时，呈现出多层吸附行为。在最佳pH值为3时，载药量可达78 mg/g，比原始静电纺丝纤维素无纺布高出20倍。此外，还发现负载NaSA的纤维素-PEI在模拟体液（SBF）中可连续释放药物12小时，这表明纤维素-PEI作为一种具有药物载体功能的先进伤口敷料具有多功能性。
