Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Koom, Menoufia, Egypt; Aachen-Maastricht Institute for Biobased Materials (AMIBM), Faculty of Science and Engineering, Maastricht University, Brightlands Chemelot Campus, Urmonderbaan 22, 6167 RD Geleen, the Netherlands.
Textile Research and Technology Institute, National Research Center (Affiliation ID: 60014618), 12622, Dokki, Giza, Egypt; Chemistry Department, Faculty of Science, New Mansoura University, New Mansoura City 35511, Egypt.
Int J Biol Macromol. 2023 Apr 1;233:123655. doi: 10.1016/j.ijbiomac.2023.123655. Epub 2023 Feb 11.
Long-term topical application of antibiotics on wounds has led to the emergence of drug-resistant bacterial infections. Antibiotic incorporation into the wound dressing requires enormous advancement of the field to ensure that the needed dose is released when the infection arises. This study synthesized a series of antimicrobial α-aminophosphonate derivatives, and the most effective compound was incorporated into thermoresponsive wound dressing patches. Wound dressing mats were fabricated by needleless electrospinning, and the resultant nanofiber mats were coated with a thermoresponsive eicosane/cellulose nanocrystals o/w system loaded with active α-aminophosphonate derivatives. Chemical, physical, thermal, and antimicrobial properties of the wound dressings were characterized wound dressings. Using SEM analysis, Nanofibers spun with 20 % w/v solutions were selected for drug-emulsion loading since they showed lower diameters with higher surface area. Furthermore, the drug-emulsion coating on the electrospun dressings improved the hydrophilicity of the wound dressings, and the thermoresponsive behavior of the mats was proved using differential scanning calorimetry data. Finally, the drug-loaded electrospun meshes were found active against tested microorganisms, and clear inhibition zones were observed. In conclusion, this novel approach of synthesizing a new family of antimicrobial molecules and their incorporation into nanofibers from renewable sources exhibits great potential for smart and innovative dressings.
长期将抗生素应用于伤口会导致耐药菌感染的出现。将抗生素纳入伤口敷料需要该领域的巨大进步，以确保在感染发生时释放所需的剂量。本研究合成了一系列抗菌α-氨基膦酸酯衍生物，其中最有效的化合物被掺入温敏性伤口敷料贴片中。通过无针静电纺丝制备了伤口敷料垫，所得的纳米纤维垫用载有活性α-氨基膦酸酯衍生物的温敏性二十烷/纤维素纳米晶体 o/w 体系进行了涂层。对伤口敷料进行了化学、物理、热学和抗菌性能的表征。通过 SEM 分析，选择了 20%w/v 溶液纺制的纳米纤维用于药物乳液负载，因为它们具有较低的直径和更高的表面积。此外，药物乳液的涂层提高了伤口敷料的亲水性，并且通过差示扫描量热法数据证明了垫子的温敏性行为。最后，发现载药的静电纺丝网对测试的微生物具有活性，并观察到清晰的抑菌圈。总之，这种合成新型抗菌分子并将其从可再生资源掺入纳米纤维的新方法为智能和创新型敷料展示了巨大的潜力。
