Hsiao Wei-Cheng, Hong Yong-Han, Tsai Yung-Hsiang, Lee Yi-Chen, Patel Anil Kumar, Guo Hui-Ru, Kuo Chia-Hung, Huang Chun-Yung
Division of Gastroenterology (General Medicine), Department of Internal Medicine, Yuan's General Hospital, No. 162, Cheng Kung 1st Rd., Lingya District, Kaohsiung City 80249, Taiwan.
Department of Nutrition, I-Shou University (Yanchao Campus), No. 8, Yida Rd., Jiaosu Village, Yanchao District, Kaohsiung City 82445, Taiwan.
Polymers (Basel). 2022 Apr 28;14(9):1812. doi: 10.3390/polym14091812.
In the current investigation, a native crude fucoidan (Ex) was extracted from , pretreated by single-screw extrusion, and two degraded fucoidans, i.e., ExAh (degradation of Ex by ascorbic acid) and ExHp (degradation of Ex by hydrogen peroxide), were obtained. The extrusion pretreatment increased the extraction yield of fucoidan by approximately 1.73-fold as compared to the non-extruded sample. Among Ex, ExAh, and ExHp, their molecular weight and chemical compositions varied, but the structural features were similar. ExHp possessed the greatest antioxidant activities among the extracted fucoidans. According to the outcome, ExAh exhibited the maximum immune promoting effects via enhanced NO, TNF-α, IL-1β, IL-6, and IL-10 secretion. Thus, both ExHp and ExAh may potentially be used as an effective antioxidant and as immunostimulant agents, which could be of great value in the development of food and nutraceutical products.
在当前的研究中，从[具体来源未给出]中提取了一种天然粗制岩藻依聚糖（Ex），并通过单螺杆挤压进行预处理，得到了两种降解的岩藻依聚糖，即ExAh（通过抗坏血酸对Ex进行降解）和ExHp（通过过氧化氢对Ex进行降解）。与未挤压的样品相比，挤压预处理使岩藻依聚糖的提取产率提高了约1.73倍。在Ex、ExAh和ExHp中，它们的分子量和化学组成有所不同，但结构特征相似。ExHp在所提取的岩藻依聚糖中具有最强的抗氧化活性。根据结果，ExAh通过增强一氧化氮（NO）、肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）和白细胞介素-10（IL-10）的分泌表现出最大的免疫促进作用。因此，ExHp和ExAh都有可能用作有效的抗氧化剂和免疫刺激剂，这在食品和营养保健品的开发中可能具有重要价值。
