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（使君子科）叶水乙醇提取物对东莨菪碱诱导的斑马鱼认知障碍中胆碱能系统功能障碍和氧化应激的神经保护潜力。

Neuroprotective Potential of (Combretaceae) Leaf Hydroethanolic Extract against Cholinergic System Dysfunctions and Oxidative Stress in Scopolamine-Induced Cognitive Impairment in Zebrafish ().

作者信息

Damo Jorelle Linda Kamda, Boiangiu Razvan Stefan, Brinza Ion, Kenko Djoumessi Léa Blondelle, Rebe Roland Nhouma, Kamleu Balbine Nkwingwa, Guedang Simon Désiré Nyayi, Camdi Guillaume Woumitna, Bouvourné Parfait, Keugong Eglantine Wado, Ngatanko Hervé Hervé Abaïssou, Cioanca Oana, Hancianu Monica, Foyet Harquin Simplice, Hritcu Lucian

机构信息

Department of Biological Sciences, Faculty of Science, University of Maroua, Maroua P.O. Box 814, Cameroon.

Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, 700506 Iasi, Romania.

出版信息

Plants (Basel). 2022 Apr 24;11(9):1149. doi: 10.3390/plants11091149.

DOI:10.3390/plants11091149
PMID:35567150
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9100236/
Abstract

JF Gmel. (Combretaceae) (GS) is a plant used in traditional medicine in West Africa for the treatment of several diseases, such as epilepsy and depression. However, its potential benefits in improving scopolamine (Sco)-induced memory impairment and brain oxidative stress in zebrafish have been investigated. In the present study, zebrafish () were treated with GS (1, 4, and 8 μg/L) for 19 days as well as Sco (100 µM) 30 min before behavioral tests. Behavioral performance was assessed by the Y-maze test and novel object recognition test (NOR), whereas anxiety response was evaluated in the novel tank diving test (NTT). Subsequently, high-performance liquid chromatography (HPLC) was used to evaluate the GS chemical composition. Sco promoted oxidative stress and acetylcholinesterase (AChE) activity. Moreover, both oxidative stress parameters and AChE activity were ameliorated by GS treatment. Accordingly, the present findings further provided the potential use of GS as a natural, alternative treatment against cognitive disorders associated to Alzheimer's disease (AD).

摘要

JF Gmel.（使君子科）（GS）是一种在西非传统医学中用于治疗多种疾病的植物，如癫痫和抑郁症。然而，已经对其在改善东莨菪碱（Sco）诱导的斑马鱼记忆障碍和脑氧化应激方面的潜在益处进行了研究。在本研究中，斑马鱼在行为测试前30分钟用GS（1、4和8μg/L）处理19天以及用Sco（100μM）处理。通过Y迷宫测试和新物体识别测试（NOR）评估行为表现，而在新水箱潜水测试（NTT）中评估焦虑反应。随后，使用高效液相色谱（HPLC）评估GS的化学成分。Sco促进氧化应激和乙酰胆碱酯酶（AChE）活性。此外，GS处理改善了氧化应激参数和AChE活性。因此，本研究结果进一步提供了GS作为对抗与阿尔茨海默病（AD）相关的认知障碍的天然替代疗法的潜在用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9603/9100236/d7bb794ec3bb/plants-11-01149-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9603/9100236/53d8e5344bf2/plants-11-01149-g001.jpg
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Ethnopharmacological uses, phytochemistry and pharmacological activities of Guiera senegalensis J.F. Gmel. (Combretaceae).塞内加尔卫矛（Combretaceae）的民族药理学用途、植物化学和药理学活性。
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