骨髓中 ILC 与前体细胞的分化。
ILC Differentiation from Progenitors in the Bone Marrow.
机构信息
T-Cell Biology and Development Unit, Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.
Université de Nantes, CNRS, INSERM, CRCINA, Nantes, France.
出版信息
Adv Exp Med Biol. 2022;1365:7-24. doi: 10.1007/978-981-16-8387-9_2.
Innate lymphoid cells (ILCs) are a family of immune cells that possess similar functions as T cells. We review steps of central ILC development in the bone marrow of adult mice and discuss recent evidence for peripheral ILC development suggesting extramedullary sites of ILC development. We also assess the contribution of development during different phases of life towards shaping the composition of the adult ILC pool. Finally, we briefly review the local cues that lead to heterogeneity of ILCs between tissues. We propose that tissue-resident ILC progenitors may economically allow tissues to elicit rapid expansion of specific ILC types that are needed based on the nature of antigenic assaults in tissues.
先天淋巴细胞（ILCs）是一类具有与 T 细胞相似功能的免疫细胞。我们综述了成年小鼠骨髓中 ILC 发育的各个阶段，并讨论了最近关于外周 ILC 发育的证据，提示 ILC 发育存在骨髓外部位。我们还评估了不同生命阶段的发育对成年 ILC 库组成的影响。最后，我们简要回顾了导致组织间 ILC 异质性的局部线索。我们认为，组织驻留的 ILC 祖细胞可能会使组织经济地允许特定 ILC 类型的快速扩增，这是基于组织中抗原攻击的性质所必需的。
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