State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, 215123, China.
State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, 215123, China.
Biosens Bioelectron. 2022 Aug 15;210:114330. doi: 10.1016/j.bios.2022.114330. Epub 2022 May 4.
Numerous polymeric agents have been widely applied in biology and medicine by virtue of the facile chemical modification, feasible nano-engineering approaches and fine-tuned pharmacokinetics. To endow polymeric imaging agents with ability to monitor and measure subtle molecular or cellular alterations at diseased sites, activatable polymeric probes that can elicit signal changes in response to biomolecular interactions or the analytes of interest have to be developed. Herein, this review aims to provide a systemic interpretation and summarization of the design methodology and imaging utility of recently emerged activatable polymeric probes. An introduction of activatable probes allowing for precise imaging and classification of polymeric imaging agents is reported first. Then, we give a detailed discussion of the contemporary design approaches toward activatable polymeric probes in diverse imaging modes for the detection of various stimuli and their imaging applications. Finally, current challenges and future advances are discussed and highlighted.
许多聚合剂由于其易于进行化学修饰、可行的纳米工程方法和精细调整的药代动力学，已被广泛应用于生物学和医学领域。为了赋予聚合成像剂监测和测量疾病部位细微分子或细胞变化的能力，必须开发能够响应生物分子相互作用或感兴趣的分析物引发信号变化的“激活型”聚合探针。在此，本综述旨在对新兴的“激活型”聚合探针的设计方法和成像应用进行系统的解释和总结。本文首先介绍了允许对聚合成像剂进行精确成像和分类的激活型探针。然后，我们详细讨论了用于检测各种刺激物及其成像应用的不同成像模式下的激活型聚合探针的当代设计方法。最后，讨论并强调了当前的挑战和未来的进展。
