Division of Reproductive Immunoendocrinology, Department of Obstetrics & Gynecology, Faculty of Medicine, University of Indonesia-Cipto Mangunkusumo National Hospital, Jl. Pangeran Diponegoro No.71, Kenari, Kec. Senen, Kota Jakarta Pusat, Daerah Khusus Ibukota Jakarta, 10430, Indonesia.
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia-Cipto Mangunkusumo National Hospital, Jl. Pangeran Diponegoro No.71, Kenari, Kec. Senen, Kota Jakarta Pusat, Daerah Khusus Ibukota Jakarta, 10430, Indonesia.
BMC Womens Health. 2022 May 14;22(1):172. doi: 10.1186/s12905-022-01756-4.
The purpose of this research was to investigate whether high AMH levels in PCOS patients resulted in different IVF outcomes compared to those in non-PCOS patients.
A retrospective cohort study was conducted involving 238 women undergoing IVF who had AMH levels > 4 ng/ml. Participants were divided into two groups: PCOS and non-PCOS.
The median AMH level was significantly higher in the PCOS group (7.59 ± 4.61 ng/ml vs. 5.91 ± 2.22 ng/ml, p < 0.001). The PCOS group required less gonadotropin but yielded more oocytes after stimulation. Significantly more participants from the PCOS group (41.5% [n = 39]) developed a hyperresponse to ovarian stimulation compared to the non-PCOS group (26.4% [n = 38]) (OR = 1.978, 95% CI 1.138-3.488; p = 0.015).
There were significant differences in terms of total doses of gonadotropin and the number of oocytes retrieved in the PCOS and non-PCOS groups. Women with PCOS and high AMH levels have a higher risk of hyperresponse after ovarian stimulation than women without PCOS.
本研究旨在探讨多囊卵巢综合征（PCOS）患者的 AMH 水平是否高于非 PCOS 患者，进而对体外受精（IVF）结局产生影响。
采用回顾性队列研究，纳入 238 例行 IVF 且 AMH 水平>4ng/ml 的患者。根据是否患有 PCOS 将患者分为 PCOS 组和非 PCOS 组。
PCOS 组的 AMH 水平中位数显著高于非 PCOS 组（7.59±4.61ng/ml 比 5.91±2.22ng/ml，p<0.001）。与非 PCOS 组相比，PCOS 组需要更少的促性腺激素，但刺激后产生的卵母细胞更多。与非 PCOS 组（26.4%[n=38]）相比，PCOS 组（41.5%[n=39]）有更多的参与者发生卵巢刺激过度反应（OR=1.978，95%CI 1.138-3.488；p=0.015）。
在 PCOS 组和非 PCOS 组中，促性腺激素的总剂量和获取的卵母细胞数量存在显著差异。与非 PCOS 患者相比，PCOS 且 AMH 水平较高的女性在卵巢刺激后发生过度反应的风险更高。
