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IgD-CD27-CD38 B 细胞频率增加及其与 ANCA 相关性血管炎肾损害的关系。

Increased frequency of IgD-CD27CD38 B cells and its association with the renal involvement in ANCA-associated vasculitis.

机构信息

Renal Division, Department of Medicine, Peking University First Hospital; Peking University Institute of Nephrology, NO.8 Xishiku Street, Xicheng District, Beijing, 100034, China.

Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China.

出版信息

Arthritis Res Ther. 2022 May 14;24(1):109. doi: 10.1186/s13075-022-02796-9.

DOI:10.1186/s13075-022-02796-9
PMID:35568913
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9107193/
Abstract

BACKGROUND

B cells have been highlighted in the pathogenesis of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) by the identification of activated B cells in granulomatous lesions and the efficacy of B cell depletion in treatment of AAV patients in the current study; we aimed to investigate the frequency of a specific B cell subset, IgD-CD27CD38 B cells in AAV patients, and its association with the disease severity of AAV.

METHODS

Blood samples of patients with AAV in active stage and in remission were collected. The frequency of IgD-CD27CD38 B cells was detected by flow cytometry, and its correlation with clinicopathological parameters was analyzed.

RESULTS

Our results showed a significant increase of circulating IgD-CD27CD38 B cells in AAV patients in active stage compared with patients in remission and healthy donors, and the frequency of IgD-CD27CD38 B cells correlated with the severity of renal involvement, including serum creatinine, estimated glomerular filtration rate, and percentages of total crescents in renal biopsies.

CONCLUSIONS

The results indicated that IgD-CD27CD38 B cells could reflect disease severity of renal involvement in AAV.

摘要

背景

通过在肉芽肿病变中鉴定活化的 B 细胞以及在当前研究中 B 细胞耗竭治疗 AAV 患者的疗效，B 细胞在抗中性粒细胞胞浆抗体（ANCA）相关性血管炎（AAV）的发病机制中受到了重视；本研究旨在探讨 AAV 患者中特定 B 细胞亚群 IgD-CD27CD38 B 细胞的频率及其与 AAV 疾病严重程度的关系。

方法

采集活动期和缓解期 AAV 患者的血液样本。通过流式细胞术检测 IgD-CD27CD38 B 细胞的频率，并分析其与临床病理参数的相关性。

结果

我们的结果表明，与缓解期患者和健康供体相比，活动期 AAV 患者循环中 IgD-CD27CD38 B 细胞的频率显著增加，且 IgD-CD27CD38 B 细胞的频率与肾脏受累的严重程度相关，包括血清肌酐、估计肾小球滤过率和肾活检中总新月体的百分比。

结论

这些结果表明，IgD-CD27CD38 B 细胞可反映 AAV 患者肾脏受累的疾病严重程度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af0e/9107193/087a8d5340aa/13075_2022_2796_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af0e/9107193/672127c2d26d/13075_2022_2796_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af0e/9107193/117c16acf2c0/13075_2022_2796_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af0e/9107193/087a8d5340aa/13075_2022_2796_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af0e/9107193/672127c2d26d/13075_2022_2796_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af0e/9107193/117c16acf2c0/13075_2022_2796_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af0e/9107193/087a8d5340aa/13075_2022_2796_Fig3_HTML.jpg

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