University of Groningen, University Medical Center Groningen, Department of Medical Oncology, Groningen, the Netherlands.
University of Groningen, University Medical Center Groningen, Department of Gastroenterology and Hepatology, Groningen, the Netherlands.
Cancer Treat Rev. 2022 Jun;107:102406. doi: 10.1016/j.ctrv.2022.102406. Epub 2022 May 9.
The gut wall is the largest immune organ and forms a barrier through which gut microbiota interact with the immune system in the rest of the body. Gut microbiota composition plays a role in the strength and timing of the anticancer immune response on immune checkpoint inhibitors (ICI). Surprisingly, the effects of gut wall characteristics, such as physical barrier integrity, permeability, and activity and composition of the intestinal immune system, on response to ICI has received little attention. Here, we provide an overview of markers to characterize the gut wall and interventions that can modulate these gut wall characteristics. Finally, we present a future perspective on how these gut wall markers and interventions might be utilized and studied to improve ICI treatment strategies.
肠道壁是最大的免疫器官，它形成了一道屏障，使肠道微生物群与身体其他部位的免疫系统相互作用。肠道微生物组成在免疫检查点抑制剂 (ICI) 的抗肿瘤免疫反应的强度和时机上发挥作用。令人惊讶的是，肠道壁特征（如物理屏障完整性、通透性以及肠道免疫系统的活性和组成）对 ICI 反应的影响却很少受到关注。在这里，我们提供了一个概述，介绍了用于描述肠道壁的标志物和可以调节这些肠道壁特征的干预措施。最后，我们提出了一个未来的观点，即这些肠道壁标志物和干预措施如何被利用和研究，以改善 ICI 治疗策略。
