中国经期偏头痛患者的健康相关生活质量及其相关因素：一项横断面研究。
Health-related quality of life and associated factors in Chinese menstrual migraine patients: a cross-sectional study.
机构信息
Department of Neurology, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, China.
Department of Psychiatry, The North Sichuan Medical College, Nanchong, Sichuan Province, China.
出版信息
BMC Womens Health. 2022 May 15;22(1):177. doi: 10.1186/s12905-022-01760-8.
BACKGROUND
Menstrual migraine is a particular form of migraine with a significant impact on the quality of life for women afflicted. Presently, no study has reported the quality of life in menstrual migraine patients. This work aims to assess the health-related quality of life and identify its associated factors among Chinese menstrual migraine patients.
METHODS
The cross-sectional study group consisted of 109 patients with menstrual migraine, and the control group consisted of 397 female patients with non-menstrual migraine. In total, 506 patients completed questionnaires for demographic and clinical information, the Self-rating Idea of Suicide Scale, the Hamilton Depression Scale, the Hamilton Anxiety Scale, the Headache Impact Test-6, the Perceived Social Support Scale, the Pittsburgh Sleep Quality Index. Health-related quality of life was measured using the 36-Item Short Form Survey.
RESULTS
Compared with non-menstrual migraine patients, five dimensions of health-related quality of life were all found to be significantly impaired in menstrual migraine patients. Headache frequency (ß = - 0.218, P = 0.014), the impact of headache on daily life (ß = - 0.270, P = 0.002), depression symptoms (ß = - 0.345, P < 0.001) were significantly associated with physical component summary, depression symptoms (ß = - 0.379, P < 0.001), social support (ß = 0.270, P < 0.001), suicidal ideation (ß = - 0.344, P < 0.001) were closely related to mental component summary.
CONCLUSION
Menstrual migraine patients had a significantly poorer health-related quality of life in many domains than non-menstrual migraine patients. Headache frequency, the impact of headache on daily life, depression symptoms, social support, and suicidal ideation were significantly associated with health-related quality of life in menstrual migraine patients.
TRIAL REGISTRATION
ChiCTR1800014343. This study was registered prospectively on 7 January 2018 at Chinese Clinical Trial registry. http://www.chictr.org.cn/showproj.aspx?proj=24526.
背景
经期偏头痛是偏头痛的一种特殊形式，对受影响女性的生活质量有重大影响。目前，尚无研究报告经期偏头痛患者的生活质量。本研究旨在评估中国经期偏头痛患者的健康相关生活质量，并确定其相关因素。
方法
采用横断面研究方法，共纳入 109 例经期偏头痛患者作为观察组，397 例非经期偏头痛患者作为对照组。共 506 例患者完成了人口学和临床信息、自杀意念自评量表、汉密尔顿抑郁量表、汉密尔顿焦虑量表、头痛影响测试-6、感知社会支持量表、匹兹堡睡眠质量指数的问卷调查。采用 36 项简明健康状况调查问卷评估健康相关生活质量。
结果
与非经期偏头痛患者相比，经期偏头痛患者的健康相关生活质量五个维度均显著受损。头痛发作频率（ß= -0.218，P=0.014）、头痛对日常生活的影响（ß= -0.270，P=0.002）、抑郁症状（ß= -0.345，P<0.001）与生理成分总分显著相关；抑郁症状（ß= -0.379，P<0.001）、社会支持（ß= 0.270，P<0.001）、自杀意念（ß= -0.344，P<0.001）与心理成分总分密切相关。
结论
与非经期偏头痛患者相比，经期偏头痛患者在许多领域的健康相关生活质量明显较差。头痛发作频率、头痛对日常生活的影响、抑郁症状、社会支持和自杀意念与经期偏头痛患者的健康相关生活质量显著相关。
试验注册
ChiCTR1800014343。本研究于 2018 年 1 月 7 日在中国临床试验注册中心进行了前瞻性注册，网址为：http://www.chictr.org.cn/showproj.aspx?proj=24526。
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