King's College London (KCL), Institute of Psychiatry, Psychology and Neuroscience (IoPPN), Psychological Medicine, London, UK.
King's College London, Centre for Neuroimaging Sciences, London, UK.
Eur Eat Disord Rev. 2022 Sep;30(5):459-473. doi: 10.1002/erv.2910. Epub 2022 May 15.
Cortical differences have been reported in Anorexia Nervosa (AN) compared with healthy controls (HC); however, it is unclear if Autism Spectrum Disorder (ASD) characteristics are related to these cortical differences. The aim of this study was to examine if structural measures were correlated to ASD traits in AN. In total 184 female participants participated in the study; 57 acutely underweight AN participants (AAN), 59 weight-restored participants (WR) and 68 HC. Participants underwent structural magnetic resonance imaging as well as completing the Autism Diagnostic Observation schedule, second edition to examine ASD characteristics. Group differences in curvature, gyrification, surface area, thickness, global grey matter and white matter were measured. Correlation and regression analysis were conducted to examine the relationship between cortical measures and ASD characteristics. Two decreased gyrification clusters in the right post central and supramarginal gyrus and decreased global grey matter were observed in the AAN group compared to HC and WR. No correlations between ASD traits and structural measures existed. Our results suggest structural differences seen in individuals with AN do not appear to be related to ASD characteristics.
与健康对照组 (HC) 相比，厌食症 (AN) 患者的皮质存在差异；然而，目前尚不清楚自闭症谱系障碍 (ASD) 特征是否与这些皮质差异有关。本研究旨在探讨 AN 中结构测量是否与 ASD 特征相关。共有 184 名女性参与者参与了这项研究；57 名急性体重不足的 AN 参与者 (AAN)、59 名体重恢复的参与者 (WR) 和 68 名 HC。参与者接受了结构磁共振成像，并完成了自闭症诊断观察量表，第二版，以检查 ASD 特征。测量了曲率、脑回、表面积、厚度、全脑灰质和白质的组间差异。进行了相关性和回归分析，以检查皮质测量值与 ASD 特征之间的关系。与 HC 和 WR 相比，AAN 组在右侧中央后回和缘上回观察到两个减少的脑回和减少的全脑灰质。ASD 特征与结构测量值之间没有相关性。我们的结果表明，AN 患者中出现的结构差异似乎与 ASD 特征无关。
