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线粒体移植改善骨关节炎的发展与进程。

Mitochondrial Transplantation Ameliorates the Development and Progression of Osteoarthritis.

作者信息

Lee A Ram, Woo Jin Seok, Lee Seon-Yeong, Na Hyun Sik, Cho Keun-Hyung, Lee Yeon Su, Lee Jeong Su, Kim Seon Ae, Park Sung-Hwan, Kim Seok Jung, Cho Mi-La

机构信息

Rheumatism Research Center, College of Medicine, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul 06591, Korea.

Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.

出版信息

Immune Netw. 2022 Jan 21;22(2):e14. doi: 10.4110/in.2022.22.e14. eCollection 2022 Apr.

DOI:10.4110/in.2022.22.e14
PMID:35573148
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9066007/
Abstract

Osteoarthritis (OA) is a common degenerative joint disease characterized by breakdown of joint cartilage. Mitochondrial dysfunction of the chondrocyte is a risk factor for OA progression. We examined the therapeutic potential of mitochondrial transplantation for OA. Mitochondria were injected into the knee joint of monosodium iodoacetate-induced OA rats. Chondrocytes from OA rats or patients with OA were cultured to examine mitochondrial function in cellular pathophysiology. Pain, cartilage destruction, and bone loss were improved in mitochondrial transplanted-OA rats. The transcript levels of IL-1β, TNF-α, matrix metallopeptidase 13, and MCP-1 in cartilage were markedly decreased by mitochondrial transplantation. Mitochondrial function, as indicated by membrane potential and oxygen consumption rate, in chondrocytes from OA rats was improved by mitochondrial transplantation. Likewise, the mitochondrial function of chondrocytes from OA patients was improved by coculture with mitochondria. Furthermore, inflammatory cell death was significantly decreased by coculture with mitochondria. Mitochondrial transplantation ameliorated OA progression, which is caused by mitochondrial dysfunction. These results suggest the therapeutic potential of mitochondrial transplantation for OA.

摘要

骨关节炎（OA）是一种常见的退行性关节疾病，其特征是关节软骨破坏。软骨细胞的线粒体功能障碍是OA进展的一个危险因素。我们研究了线粒体移植对OA的治疗潜力。将线粒体注入碘乙酸钠诱导的OA大鼠膝关节。培养OA大鼠或OA患者的软骨细胞，以检查细胞病理生理学中的线粒体功能。线粒体移植的OA大鼠的疼痛、软骨破坏和骨质流失得到改善。线粒体移植显著降低了软骨中IL-1β、TNF-α、基质金属蛋白酶13和MCP-1的转录水平。线粒体移植改善了OA大鼠软骨细胞的线粒体功能，表现为膜电位和氧消耗率。同样，与线粒体共培养改善了OA患者软骨细胞的线粒体功能。此外，与线粒体共培养显著减少了炎症细胞死亡。线粒体移植改善了由线粒体功能障碍引起的OA进展。这些结果表明线粒体移植对OA具有治疗潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a6/9066007/2114c8c56d32/in-22-e14-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a6/9066007/3a3a96114a2f/in-22-e14-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a6/9066007/d75356b8451e/in-22-e14-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a6/9066007/aab3f7caeb01/in-22-e14-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a6/9066007/b6ab225779e6/in-22-e14-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a6/9066007/1be1be33e925/in-22-e14-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a6/9066007/2114c8c56d32/in-22-e14-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a6/9066007/3a3a96114a2f/in-22-e14-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a6/9066007/d75356b8451e/in-22-e14-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a6/9066007/aab3f7caeb01/in-22-e14-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a6/9066007/b6ab225779e6/in-22-e14-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a6/9066007/1be1be33e925/in-22-e14-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a6/9066007/2114c8c56d32/in-22-e14-g006.jpg

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