Sofizan Nik Muhammad Faiz Bin Nik, Rahman Ahmad Faiz Bin Abd, Soon Lai Poh, Ly Chng Kay, Abdullah Nor Zamzila Bt
Kulliyyah of Medicine, International Islamic University Malaysia, 25200 Kuantan, Pahang Malaysia.
National Institute of Forensic Medicine (NIFM), Kuala Lumpur Hospital, Jalan Pahang, 50586 Kuala Lumpur, Wilayah Persekutuan Malaysia.
Egypt J Forensic Sci. 2022;12(1):22. doi: 10.1186/s41935-022-00280-8. Epub 2022 May 10.
Coronavirus-19 disease (COVID-19) has been declared as pandemic by the World Health Organization (WHO) in March 2020. As of 28 November 2021, there were more than 260 million cases and nearly 5.2 million deaths caused by COVID-19. The most affected system by COVID-19 infection was the respiratory system although several other studies suggested multi-organ involvement with pathophysiology that was not clearly understood. Autopsy findings were beneficial to researchers to determine the mechanism behind these organ failures. The objective of this review was to summarize the autopsy findings related to COVID-19 death.
Online literature search was conducted via online databases such as Scopus, PubMed and Google Scholar. The keywords inputted during the search were "post-mortem", "autopsy" and "COVID-19" in title, abstract and keywords. The inclusion criteria were the topic related with the title of this review, published in 2020-2021, have full text available and in English language. Any articles that were not related, duplicated studies, review articles including systematic review and meta-analysis and in other languages were excluded.
A total of 20 articles were included in this review. The articles reviewed were mostly case reports and case series while others were case-control and cohort study ranging from one to 348 cases. Majority were originated from the United States of America (USA).
The most frequent system described in autopsy findings in COVID-19 death was the respiratory system, with the most common histological finding of diffuse alveolar damage (DAD). Majority of the findings of other organs were related to chronic diseases.
2020年3月，世界卫生组织（WHO）宣布新型冠状病毒肺炎（COVID-19）为大流行病。截至2021年11月28日，COVID-19已导致超过2.6亿例病例和近520万人死亡。尽管其他一些研究表明COVID-19感染会累及多个器官，但其病理生理学尚不清楚，但受COVID-19感染影响最严重的系统是呼吸系统。尸检结果有助于研究人员确定这些器官衰竭背后的机制。本综述的目的是总结与COVID-19死亡相关的尸检结果。
通过Scopus、PubMed和谷歌学术等在线数据库进行在线文献检索。检索期间输入的关键词为标题、摘要和关键词中的“尸检”“解剖”和“COVID-19”。纳入标准为与本综述标题相关、于2020年至2021年发表、有全文且为英文的主题。任何不相关的文章、重复研究、包括系统评价和荟萃分析在内的综述文章以及其他语言的文章均被排除。
本综述共纳入20篇文章。所综述的文章大多为病例报告和病例系列，其他为病例对照研究和队列研究，病例数从1例到348例不等。大多数文章来自美利坚合众国（美国）。
COVID-19死亡尸检结果中描述最频繁的系统是呼吸系统，最常见的组织学发现是弥漫性肺泡损伤（DAD）。其他器官的大多数发现与慢性疾病有关。
