Ding Guocheng, Du Jianing, Hu Xiaoqing, Ao Yingfang
Institute of Sports Medicine, Peking University Third Hospital, Beijing, China.
School of Basic Medical Sciences, Peking University, Beijing, China.
Front Bioeng Biotechnol. 2022 Apr 27;10:796367. doi: 10.3389/fbioe.2022.796367. eCollection 2022.
Meniscus damage is a common trauma that often arises from sports injuries or menisci tissue degeneration. Current treatment methods focus on the repair, replacement, and regeneration of the meniscus to restore its original function. The advance of tissue engineering provides a novel approach to restore the unique structure of the meniscus. Recently, mesenchymal stem cells found in tissues including bone marrow, peripheral blood, fat, and articular cavity synovium have shown specific advantages in meniscus repair. Although various studies explore the use of stem cells in repairing meniscal injuries from different sources and demonstrate their potential for chondrogenic differentiation, their meniscal cartilage-forming properties are yet to be systematically compared. Therefore, this review aims to summarize and compare different sources of mesenchymal stem cells for meniscal repair and regeneration.
半月板损伤是一种常见的创伤，通常由运动损伤或半月板组织退变引起。目前的治疗方法侧重于半月板的修复、置换和再生，以恢复其原有功能。组织工程学的进展为恢复半月板独特结构提供了一种新方法。最近，在包括骨髓、外周血、脂肪和关节腔滑膜等组织中发现的间充质干细胞在半月板修复中显示出特定优势。尽管各种研究探索了不同来源的干细胞在修复半月板损伤中的应用，并证明了它们的软骨形成分化潜力，但它们形成半月板软骨的特性尚未得到系统比较。因此，本综述旨在总结和比较用于半月板修复和再生的不同来源间充质干细胞。
