Ramchoun Mhamed, Khouya Tarik, Harnafi Hicham, Amrani Souliman, Alem Chakib, Benlyas Mohamed, Kasbi Chadli Fatima, Nazih El-Hassane, Nguyen Patrick, Ouguerram Khadija
Laboratory of Biotechnology & Sustainable Development of Natural Resources, Polydisciplinary Faculty, University of Sultan Moulay Slimane, Beni Mellal 23000, Morocco.
Biochemistry and Natural Substances Team, Department of Biology, Faculty of Sciences & Techniques, University of Moulay Ismail, Errachidia 52000, Morocco.
Evid Based Complement Alternat Med. 2020 Mar 28;2020:3282596. doi: 10.1155/2020/3282596. eCollection 2020.
, an endemic plant of Morocco, is traditionally used as a liniment or a drink to treat various diseases. However, there are few available scientific data regarding its biological effects. In this connection, the present study aimed to investigate the hypolipidemic and antioxidant effects of aqueous extract and polyphenol fraction of in Syrian golden hamsters treated with Triton WR-1339 (triton, 20 mg/100 g body weight). The hamsters orally received the extracts (400 mg/kg), and blood samples were collected after 24 h of treatment to determine plasma lipid, insulin, and fasting blood glucose levels. Plasma malondialdehyde level and plasma total antioxidant (TAS) were also evaluated. The extracts significantly decreased triglycerides, total cholesterol, VLDL-C, and LDL-C and increased HDL-C when compared with the hyperlipidemic group. Both extracts suppressed the effect of the triton injection on TAS and reduced the level of plasma malondialdehyde. The extracts produced no significant change in the blood glucose level but effectively prevented the mild hyperinsulinemia induced by triton. These findings suggest that may be a useful alternative treatment for the control of hyperlipidemia and its related diseases.
作为摩洛哥的一种本土植物，传统上被用作擦剂或饮品来治疗各种疾病。然而，关于其生物学效应的科学数据却很少。就此，本研究旨在调查在经Triton WR - 1339（曲拉通，20毫克/100克体重）处理的叙利亚金仓鼠中，[植物名称]水提取物和多酚组分的降血脂和抗氧化作用。仓鼠口服给予提取物（400毫克/千克），治疗24小时后采集血样以测定血浆脂质、胰岛素和空腹血糖水平。还评估了血浆丙二醛水平和血浆总抗氧化能力（TAS）。与高脂血症组相比，[植物名称]提取物显著降低了甘油三酯、总胆固醇、极低密度脂蛋白胆固醇（VLDL - C）和低密度脂蛋白胆固醇（LDL - C），并提高了高密度脂蛋白胆固醇（HDL - C）。两种提取物均抑制了曲拉通注射对TAS的影响，并降低了血浆丙二醛水平。提取物对血糖水平无显著影响，但有效预防了曲拉通诱导的轻度高胰岛素血症。这些发现表明，[植物名称]可能是控制高脂血症及其相关疾病的一种有用的替代治疗方法。
