Suzuki Y, Kobayashi A
Infect Immun. 1987 Apr;55(4):1017-8. doi: 10.1128/iai.55.4.1017-1018.1987.
In mice infected with an avirulent strain of Toxoplasma gondii, circulating Toxoplasma antigens were detectable in the sera during weeks 1 to 3 of infection by a simple agglutination test that uses latex particles coated with anti-Toxoplasma antibodies. An infection in athymic nude mice resulted in high agglutination titers in the anti-Toxoplasma antibody-coated latex particle test and the absence of anti-Toxoplasma antibodies in sera during the acute phase, suggesting that the detection of circulating Toxoplasma antigens is a good tool for the diagnosis of acute toxoplasmosis, especially in severely immunocompromised hosts.
在感染了无毒力弓形虫株的小鼠中，在感染的第1至3周期间，通过使用涂有抗弓形虫抗体的乳胶颗粒的简单凝集试验，可在血清中检测到循环中的弓形虫抗原。无胸腺裸鼠感染后，在抗弓形虫抗体包被的乳胶颗粒试验中出现高凝集滴度，且急性期血清中不存在抗弓形虫抗体，这表明循环中弓形虫抗原的检测是诊断急性弓形虫病的良好工具，尤其是在严重免疫功能低下的宿主中。
