Department of Health Behavior, School of Public Health, University of Alabama at Birmingham, USA; Department of Psychology, University of Alabama at Birmingham, USA.
Department of Health Behavior, School of Public Health, University of Alabama at Birmingham, USA.
Neuropharmacology. 2022 Aug 15;214:109127. doi: 10.1016/j.neuropharm.2022.109127. Epub 2022 May 13.
Psilocybin-facilitated psychotherapy shows potential transdiagnostic efficacy for a range of mental health conditions. Though vulnerable populations bear disproportionate mental health burden, they have been largely neglected in the clinical psilocybin literature. However, if the field is to best respond to the diverse needs of individuals from vulnerable populations, care must be taken to ensure these individuals are represented in the empirical research. This report calls attention to this concern by detailing the challenges and opportunities associated with evaluating psilocybin-facilitated psychotherapy in vulnerable populations. First, we show how working with vulnerable populations must be considered in the context of an often-problematic past and differential exposure to and experience with classic psychedelics. We then provide actionable recommendations for future research testing psilocybin-facilitated psychotherapy in vulnerable populations, including an emphasis on recruitment strategies, the appropriate communication and assessment of subjective effects, building therapeutic alliance, multicultural competence, and flexible study designs. On these premises we call for future work in this area, underscoring that there is vast room for improvement and expansion in this rapidly advancing field of study.
迷幻蘑菇辅助心理治疗对一系列心理健康状况显示出潜在的跨诊断疗效。尽管弱势群体承受着不成比例的精神健康负担，但他们在迷幻蘑菇的临床文献中基本上被忽视了。然而，如果该领域要最好地满足弱势群体个体的多样化需求，就必须注意确保这些个体在实证研究中得到代表。本报告通过详细说明在弱势群体中评估迷幻蘑菇辅助心理治疗相关的挑战和机遇，提请人们注意这一问题。首先，我们展示了在一个常常存在问题的过去的背景下，以及在接触和体验经典迷幻剂方面的差异，必须考虑到与弱势群体合作的问题。然后，我们为未来在弱势群体中测试迷幻蘑菇辅助心理治疗的研究提供了切实可行的建议，包括强调招募策略、适当的沟通和主观效果评估、建立治疗联盟、多元文化能力和灵活的研究设计。在此基础上，我们呼吁在这一领域开展未来的工作，强调在这个快速发展的研究领域有很大的改进和拓展空间。
