Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université de Toulouse, Centre National de la Recherche Scientifique (CNRS), Université Paul Sabatier, Toulouse 31062, France.
Learn Mem. 2022 May 16;29(6):142-145. doi: 10.1101/lm.053555.121. Print 2022 Jun.
Dopamine participates in encoding memories and could either encode rewarding/aversive value of unconditioned stimuli or act as a novelty signal triggering contextual learning. Here we show that intraperitoneal injection of the dopamine D1/5R antagonist SCH23390 impairs contextual fear conditioning and tone-shock association, while intrahippocampal injection only impairs contextual fear conditioning. By using the context pre-exposure facilitation effect test, we show that SCH23390 is able to block the encoding of the context during the pre-exposure phase. Thus, we provide additional evidence that dopamine is involved in encoding conjunctive representations of new contexts.
多巴胺参与记忆编码，可以编码无条件刺激的奖励/厌恶值，或者作为触发情境学习的新颖性信号。在这里，我们表明，腹腔内注射多巴胺 D1/5R 拮抗剂 SCH23390 会损害情境性恐惧条件反射和音调-电击关联，而海马内注射仅损害情境性恐惧条件反射。通过使用情境预暴露促进效应测试，我们表明 SCH23390 能够阻断预暴露阶段中情境的编码。因此，我们提供了额外的证据表明，多巴胺参与了新情境的联合表示的编码。
