Salminen A, Kihlström M
Int J Sports Med. 1987 Feb;8(1):46-9. doi: 10.1055/s-2008-1025639.
The role of prostaglandin synthesis was evaluated by indomethacin administration in the pathogenesis of exercise-induced muscle fiber injuries in soleus and quadriceps femoris muscles of mice. The administration of indomethacin before, during, and after 9 h exertion (s.c., 6 mg/kg during and just after exertion and 1.5-3 mg/kg before exertion and later twice a day) caused a significant histologic protection against exercise injuries and considerably reduced the exercise responses of beta-glucuronidase and glucose-6-phosphate dehydrogenase activities (enzymatic indicators of necrotic lesions in skeletal muscles) on the 2nd post-exercise day. The administration of indomethacin before and during the exertion (3 and 10 mg/kg, respectively) but not after exertion caused only a slight histologic protection while the enzymatic indicators showed a nonsignificant effect.
通过给小鼠比目鱼肌和股四头肌注射消炎痛，评估前列腺素合成在运动诱导的肌肉纤维损伤发病机制中的作用。在9小时运动前、运动期间和运动后给予消炎痛（皮下注射，运动期间和运动刚结束后为6mg/kg，运动前为1.5 - 3mg/kg，之后每天两次），在运动后第2天对运动损伤产生了显著的组织学保护作用，并显著降低了β-葡萄糖醛酸酶和葡萄糖-6-磷酸脱氢酶活性（骨骼肌坏死损伤的酶学指标）的运动反应。在运动前和运动期间给予消炎痛（分别为3mg/kg和10mg/kg），但运动后不给予，仅产生轻微的组织学保护作用，而酶学指标显示无显著影响。
